Anthony David, Diao Tianning
Department of Chemistry, New York University, 100 Washington Square E, New York, NY 10003, USA.
Synlett. 2020 Jul;31(15):1443-1447. doi: 10.1055/s-0040-1707900.
Alkenes are an appealing functional group that can be transformed into a variety of structures. Transition-metal catalyzed dicarbofunctionalization of alkenes can efficiently afford products with complex substitution patterns from simple substrates. Under reductive conditions, this transformation can be achieved while avoiding stoichiometric organometallic reagents. Asymmetric difunctionalization of alkenes has been underdeveloped, in spite of its potential synthetic utility. Herein, we present a summary of our efforts to control enantioselectivity for alkene diarylation with a nickel catalyst. This reaction is useful for preparing triarylethanes. The selectivity is enhanced by an -oxyl radical additive.
烯烃是一种具有吸引力的官能团，能够转化为多种结构。过渡金属催化的烯烃双碳官能化反应可以从简单底物高效地得到具有复杂取代模式的产物。在还原条件下，这种转化能够在避免使用化学计量的有机金属试剂的情况下实现。尽管烯烃的不对称双官能化反应具有潜在的合成应用价值，但目前该领域的研究仍不够充分。在此，我们总结了我们使用镍催化剂控制烯烃双芳基化对映选择性的研究成果。该反应可用于制备三芳基乙烷。一种 - 氧基自由基添加剂可提高选择性。
