Guo Tao, Xuan Min, Zhou Cheng, Wu Jingjing, Gao Ting, Bai Xueqin, Liu Xiaocao, Gu Luyan, Liu Ruiqi, Song Zhe, Gu Quanquan, Huang Peiyu, Pu Jiali, Zhang Baorong, Xu Xiaojun, Guan Xiaojun, Zhang Minming
Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Netw Neurosci. 2022 Jun 1;6(2):552-569. doi: 10.1162/netn_a_00232. eCollection 2022 Jun.
Hierarchical brain organization, in which the rich club and diverse club situate in core position, is critical for global information integration in the human brain network. Parkinson's disease (PD), a common movement disorder, has been conceptualized as a network disorder. Levodopa is an effective treatment for PD. Whether there is a functional divergence in the hierarchical brain system under PD pathology, and how this divergence is regulated by immediate levodopa therapy, remains unknown. We constructed a functional network in 61 PD patients and 89 normal controls and applied graph theoretical analyses to examine the neural mechanism of levodopa short response from the perspective of brain hierarchical configuration. The results revealed the following: (a) PD patients exhibited disrupted function within rich-club organization, while the diverse club preserved function, indicating a differentiated brain topological organization in PD. (b) Along the rich-club derivate hierarchical system, PD patients showed impaired network properties within rich-club and feeder subnetworks, and decreased nodal degree centrality in rich-club and feeder nodes, along with increased nodal degree in peripheral nodes, suggesting distinct functional patterns in different types of nodes. And (c) levodopa could normalize the abnormal network architecture of the rich-club system. This study provides evidence for levodopa effects on the hierarchical brain system with divergent functions.
层级式脑组织结构中，富俱乐部和多样俱乐部处于核心位置，这对于人类脑网络中的全局信息整合至关重要。帕金森病（PD）是一种常见的运动障碍，已被视为一种网络障碍。左旋多巴是治疗PD的有效药物。在PD病理状态下，层级式脑系统中是否存在功能差异，以及这种差异如何通过即时左旋多巴治疗进行调节，目前尚不清楚。我们构建了一个包含61名PD患者和89名正常对照的功能网络，并应用图论分析从脑层级结构的角度研究左旋多巴短期反应的神经机制。结果显示如下：（a）PD患者在富俱乐部组织内功能紊乱，而多样俱乐部功能保留，表明PD患者存在差异化的脑拓扑组织。（b）沿着富俱乐部衍生的层级系统，PD患者在富俱乐部和馈子网内的网络属性受损，富俱乐部和馈子节点的节点度中心性降低，同时周边节点的节点度增加，表明不同类型节点存在不同的功能模式。并且（c）左旋多巴可使富俱乐部系统异常的网络结构正常化。本研究为左旋多巴对具有不同功能的层级式脑系统的作用提供了证据。
