Mames Adam, Jopa Sylwia, Pietrzak Mariusz, Ratajczyk Tomasz
Institute of Physical Chemistry, Polish Academy of Sciences Kasprzaka 44/52 Warsaw 01-224 Poland
Faculty of Chemistry, University of Warsaw Pasteura 1 Warsaw 02-093 Poland.
RSC Adv. 2022 May 27;12(25):15986-15991. doi: 10.1039/d2ra02872g. eCollection 2022 May 23.
Signal Amplification by Reversible Exchange (SABRE) and hydrogeneable Parahydrogen Induced Polarization (hPHIP) can enhance weak NMR signals, and thus increase the range of NMR applications. Here, using an N-heterocyclic carbene Ir-based catalyst, simultaneous SABRE and hPHIP was achieved for the compound with an N-donor site and an acetylene triple bond. It was demonstrated that the interplay between SABRE and hPHIP can be manipulated. Specifically, it was found that the hPHIP effect could be almost completely suppressed, while stable SABRE was observed in subsequent consecutive experiments. The presented results have the potential to increase the numbers of parahydrogen hyperpolarizable molecules.
可逆交换信号放大（SABRE）和可氢化仲氢诱导极化（hPHIP）能够增强微弱的核磁共振（NMR）信号，从而扩大NMR的应用范围。在此，使用一种基于氮杂环卡宾铱的催化剂，实现了对具有氮供体位点和乙炔三键的化合物同时进行SABRE和hPHIP。结果表明，SABRE和hPHIP之间的相互作用是可以调控的。具体而言，研究发现hPHIP效应几乎可以被完全抑制，而在后续的连续实验中观察到了稳定的SABRE。所呈现的结果有可能增加仲氢超极化分子的数量。
