Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan, 48202, USA.
International Tomography Center SB RAS, Institutskaya St. 3A, 630090, Novosibirsk, Russia.
Chemistry. 2021 Feb 5;27(8):2774-2781. doi: 10.1002/chem.202004168. Epub 2021 Jan 7.
Many MRI contrast agents formed with the parahydrogen-induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high-throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics.
许多采用 Para 氫诱导极化（PHIP）技术形成的 MRI 对比剂具有生物相容性。在可吸入分子对比剂的呼吸成像方面，开发不可燃对比剂对于将这种敏感、高通量且经济实惠的极化技术应用于生物医学领域将具有非常重要的意义。为此，我们评估了在不同氟取代程度下 PHIP 极化产物（酸、醚和酯）的加氢动力学、极化水平和寿命。结果突出了作为分子结构函数的重要趋势，对于设计用于 PHIP 技术体内成像应用的新型安全对比剂具有指导意义，重点是用作可吸入麻醉剂的醚这一高度挥发性基团。
