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埃塞俄比亚为耐多药结核病患者提供助听器支持。

Hearing aid support for patients with DR-TB in Ethiopia.

作者信息

Teferra G, Teklemariam K, Wares D F, Negeri C, Bedru A

机构信息

KNCV Tuberculosis Foundation, Addis Ababa, Ethiopia.

Organic Health Care Service, Addis Ababa, Ethiopia.

出版信息

Public Health Action. 2022 Jun 21;12(2):74-78. doi: 10.5588/pha.21.0068.

Abstract

SETTING

Previous and current patients with drug-resistant TB (DR-TB) who had documented treatment-related hearing impairment due to second-line injectable (SLI) use were identified from different DR-TB treatment initiation centres in Ethiopia.

OBJECTIVE

To assess selected patients with DR-TB for eligibility for hearing aids and provide hearing aids to 10 eligible patients.

DESIGN

This was an observational cohort study. Patients were followed up for 8 months, with hearing assessments conducted at 1, 3 and 8 months to objectively assess hearing capacity.

RESULTS

Of 12 patients assessed for hearing aids eligibility, 10 were fitted with hearing aids (type XTM XP P4) and followed up for 8 months. "Formal" improvement was observed only in one patient. However, "general quality of life" appeared to be improved in nine patients.

CONCLUSION

Minimal "formal" improvement was observed. However, the study was too small to say whether hearing aids should, or should not, be recommended as a public health measure. This needs a larger better controlled follow-up study. The all-oral DR-TB treatment regimens should be used for all patients with DR-TB in Ethiopia. However, as a proportion of patients with DR-TB are likely to continue receiving SLIs in the foreseeable future, they will require close audiometry assessment and appropriate care.

摘要

背景

从埃塞俄比亚不同的耐多药结核病(DR-TB)治疗起始中心,识别出既往和当前因使用二线注射剂(SLI)而有记录的与治疗相关听力损害的耐多药结核病患者。

目的

评估选定的耐多药结核病患者是否适合佩戴助听器,并为10名符合条件的患者提供助听器。

设计

这是一项观察性队列研究。对患者进行8个月的随访,在第1、3和8个月进行听力评估,以客观评估听力能力。

结果

在评估是否适合佩戴助听器的12名患者中,10名患者佩戴了助听器(XTM XP P4型)并随访8个月。仅1名患者观察到“正式”改善。然而,9名患者的“总体生活质量”似乎有所改善。

结论

观察到的“正式”改善极小。然而,该研究规模太小,无法确定是否应推荐将助听器作为一项公共卫生措施。这需要进行更大规模、控制更好的随访研究。埃塞俄比亚所有耐多药结核病患者均应采用全口服耐多药结核病治疗方案。然而,由于在可预见的未来,仍有一部分耐多药结核病患者可能继续接受二线注射剂治疗,他们将需要密切的听力测定评估和适当护理。

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Hearing loss in patients on treatment for drug-resistant tuberculosis.耐多药结核病患者的听力损失。
Eur Respir J. 2012 Nov;40(5):1277-86. doi: 10.1183/09031936.00044812. Epub 2012 Jun 14.
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Aminoglycoside-induced hearing loss in humans.氨基糖苷类药物所致的人类听力损失。
Antimicrob Agents Chemother. 1989 Jun;33(6):797-800. doi: 10.1128/AAC.33.6.797.
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Ototoxicity of amikacin.阿米卡星的耳毒性。
Antimicrob Agents Chemother. 1976 Jun;9(6):956-61. doi: 10.1128/AAC.9.6.956.

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