Zheng Meifang, Gao Runping
Department of Hepatic Biliary Pancreatic Medicine, The First Hospital of Jilin University, Changchun, China.
Front Pharmacol. 2022 Jun 6;13:902639. doi: 10.3389/fphar.2022.902639. eCollection 2022.
Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas. The incidence of CP is increasing worldwide but the effective therapies are lacking. Hence, it is necessary to identify economical and effective agents for the treatment of CP patients. Vitamin D (VD) and its analogues have been confirmed as pleiotropic regulators of cell proliferation, apoptosis, differentiation and autophagy. Clinical studies show that VD deficiency is prevalent in CP patients. However, the correlation between VD level and the risk of CP remains controversial. VD and its analogues have been demonstrated to inhibit pancreatic fibrosis by suppressing the activation of pancreatic stellate cells and the production of extracellular matrix. Limited clinical trials have shown that the supplement of VD can improve VD deficiency in patients with CP, suggesting a potential therapeutic value of VD in CP. However, the mechanisms by which VD and its analogues inhibit pancreatic fibrosis have not been fully elucidated. We are reviewing the current literature concerning the risk factors for developing CP, prevalence of VD deficiency in CP, mechanisms of VD action in PSC-mediated fibrogenesis during the development of CP and potential therapeutic applications of VD and its analogues in the treatment of CP.
慢性胰腺炎（CP）是一种胰腺的慢性炎症和纤维化疾病。CP的发病率在全球范围内呈上升趋势，但缺乏有效的治疗方法。因此，有必要确定经济有效的药物来治疗CP患者。维生素D（VD）及其类似物已被确认为细胞增殖、凋亡、分化和自噬的多效性调节剂。临床研究表明，CP患者中VD缺乏很普遍。然而，VD水平与CP风险之间的相关性仍存在争议。VD及其类似物已被证明可通过抑制胰腺星状细胞的激活和细胞外基质的产生来抑制胰腺纤维化。有限的临床试验表明，补充VD可改善CP患者的VD缺乏，提示VD在CP中具有潜在的治疗价值。然而，VD及其类似物抑制胰腺纤维化的机制尚未完全阐明。我们正在综述有关CP发生的危险因素、CP中VD缺乏的患病率、CP发展过程中VD在胰腺星状细胞介导的纤维化形成中的作用机制以及VD及其类似物在CP治疗中的潜在治疗应用的当前文献。
