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连续血糖监测在儿童、青少年和青年人群 1 型糖尿病患者中的应用及其效果的相关争论。

CONTINUOUS GLUCOSE MONITORING AND TYPE 1 DIABETES MELLITUS CONTROL IN CHILD, ADOLESCENT AND YOUNG ADULT POPULATION - ARGUMENTS FOR ITS USE AND EFFECTS.

机构信息

1Department of Pediatrics, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2Department of Pediatrics, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

出版信息

Acta Clin Croat. 2021 Dec;60(4):609-616. doi: 10.20471/acc.2021.60.04.07.

DOI:10.20471/acc.2021.60.04.07
PMID:35734487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9196217/
Abstract

Sensors for continuous glucose monitoring (CGM) in intercellular fluid are used as a contemporary method to achieve better control in type 1 diabetes mellitus (DM), which is best shown through lower glycated hemoglobin (HbA1c) levels.The aim of this study was to assess how many of our patients used CGM (parents were solely financing all the cost of the device) and what was the effect of CGM on the control of DM. Data were retrospectively collected from medical records of patients actively treated at the Division of Endocrinology, Diabetology, Pulmonology and Allergology, Department of Pediatrics, Sestre milosrdnice University Hospital Center. The t-test was used for independent samples to compare the mean levels of HbA1c before and after the inclusion of CGM. CGM was used by 81 (32.1%) of our patients with type 1 DM, of which 43 met the inclusion criteria. The mean HbA1c level 6 months before the introduction of CGM was 8.2%±1.9 and after 12 months of CGM use it was 7.4%±1.2, which was a statistically significant improvement (p=0.026). Furthermore, our results demonstrated that the greatest improvement in HbA1c level was recorded in the groups of young adults (18-25 years) and youngest children (<12 years). We confirmed the efficacy of CGM in achieving better control of type 1 DM by significantly improving HbA1c levels in a population of highly motivated patients.

摘要

用于细胞间液中连续血糖监测 (CGM) 的传感器被用作实现 1 型糖尿病 (DM) 更好控制的现代方法,这在糖化血红蛋白 (HbA1c) 水平降低方面表现得最好。本研究的目的是评估我们有多少患者使用 CGM(父母完全承担设备的所有费用)以及 CGM 对 DM 控制的影响。数据是从儿科内分泌学、糖尿病学、肺病学和过敏学部门的 Sestre milosrdnice 大学医院中心的活跃患者的病历中回顾性收集的。独立样本 t 检验用于比较 CGM 纳入前后 HbA1c 的平均水平。我们有 81 名 1 型 DM 患者(32.1%)使用了 CGM,其中 43 名符合纳入标准。在引入 CGM 之前的 6 个月,HbA1c 平均水平为 8.2%±1.9,在使用 CGM 12 个月后,HbA1c 平均水平为 7.4%±1.2,这是一个具有统计学意义的改善(p=0.026)。此外,我们的结果表明,在年轻成年人(18-25 岁)和最小的儿童(<12 岁)组中,HbA1c 水平的改善最大。我们通过在高度积极的患者群体中显著改善 HbA1c 水平,证实了 CGM 在实现 1 型 DM 更好控制方面的疗效。

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