N6-甲基腺苷相关长链非编码RNA的预后特征建立及其在肝癌患者中的潜在功能

Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients.

作者信息

Wu Xianbin, Deng Zhejun, Liao Xiaomin, Ruan Xianxian, Qu Nanfang, Pang Lixing, Shi Xiaoyan, Qin Shanyu, Jiang Haixing

机构信息

Department of Gastroenterology, The First Afliated Hospital of Guangxi Medical University, Nanning, China.

Department of Gastroenterology, The Third Affifiliated Hospital of Guangxi Medical University, Nanning, China.

出版信息

Front Oncol. 2022 Jun 6;12:865917. doi: 10.3389/fonc.2022.865917. eCollection 2022.

N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC). We downloaded the expression and clinical data from The Cancer Genome Atlas (TCGA) database. The interacted mRNAs and lncRNAs, prognosis-related lncRNAs, potential metabolic pathways of lncRNAs, immune infiltration of various cells, and CD274 (PD-L1) -related lncRNAs were analyzed. Then, experiments explored the role of AC012073.1 (LOC105377626) in HCC cell lines. We found that candidate 14 lncRNA signatures play functions in HCC maybe by affecting immune infiltration, cell cycle, Notch signaling pathway, etc. LncRNA AC012073.1 (LOC105377626) functions as oncogenic roles in affecting HCC prognosis.

N6-甲基腺苷（m6A）相关的信使核糖核酸（mRNA）和长链非编码核糖核酸（lncRNA）在多种癌症中的功能已得到研究。本研究旨在确定肝细胞癌（HCC）中m6A相关lncRNA的潜在特征。我们从癌症基因组图谱（TCGA）数据库下载了表达和临床数据。分析了相互作用的mRNA和lncRNA、与预后相关的lncRNA、lncRNA的潜在代谢途径、各种细胞的免疫浸润以及与CD274（程序性死亡受体配体1，PD-L1）相关的lncRNA。然后，实验探讨了AC012073.1（LOC105377626）在肝癌细胞系中的作用。我们发现，候选的14个lncRNA特征可能通过影响免疫浸润、细胞周期、Notch信号通路等在肝癌中发挥作用。lncRNA AC012073.1（LOC105377626）在影响肝癌预后方面发挥致癌作用。