School of Biological Sciences, Queen's University Belfast, 19 Chlorine Gardens, Belfast, Northern Ireland, UK.
Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Parasitology. 2022 Sep;149(10):1257-1261. doi: 10.1017/S0031182022000877. Epub 2022 Jun 23.
Foodborne trematodes (FBTs) have a worldwide distribution (with particular prevalence in south-east Asia) and are believed to infect almost 75 million people, with millions more living at risk of infection. Although mortality due to trematodiasis is low, these infections cause considerable morbidity and some species are associated with the development of cancer in hyperendemic regions. Despite this, FBTs are often side-lined in terms of research funding and have been dubbed neglected tropical diseases by the World Health Organisation. Thus, the aim of this special issue was to provide an update of our understanding of FBT infections, to shine a light on current work in the field and to highlight some research priorities for the future. With contributions from leading researchers, many from endemic regions, we review the major FBT species. In doing so we revisit some old foes, uncover emerging infections and discover how outbreaks are being dealt with as a result of new approaches to parasite control. We also report advances in our understanding of the interactions of FBTs with their mammalian hosts and uncover new interplay between trematodes and host microbiome components. We hope that this article collection will stimulate discussion and further research on the FBTs and help raise them from their neglected status.
食源性吸虫（FBTs）分布广泛（在东南亚尤为流行），据信几乎感染了 7500 万人，还有数百万人面临感染风险。尽管吸虫病的死亡率较低，但这些感染会导致相当多的发病率，并且有些物种与高流行地区癌症的发展有关。尽管如此，FBTs 在研究资金方面往往被边缘化，并被世界卫生组织称为被忽视的热带病。因此，本期特刊的目的是提供对 FBT 感染的最新认识，关注该领域的当前工作，并强调未来的一些研究重点。本期特刊汇集了来自主要研究人员的贡献，其中许多来自流行地区，我们回顾了主要的 FBT 物种。在这样做的过程中，我们重新审视了一些旧敌，发现了新的感染，并了解了由于寄生虫控制的新方法，如何应对暴发。我们还报告了我们对 FBT 与哺乳动物宿主相互作用的理解的进展，并揭示了吸虫和宿主微生物组成分之间新的相互作用。我们希望这篇文章集能够激发关于 FBTs 的讨论和进一步的研究，并帮助它们摆脱被忽视的地位。
