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长链非编码 RNA ZNF503 反义 RNA 1 参与糖尿病视网膜病变及其可能的作用机制。

Involvement of long non-coding RNA ZNF503 antisense RNA 1 in diabetic retinopathy and its possible underlying mechanism.

机构信息

Department of Nursing and Health, Nanfang College-Guangzhou, Guangzhou, Guangdong, China.

Department of Rheumatism, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China.

出版信息

Bioengineered. 2022 Jun;13(6):14057-14065. doi: 10.1080/21655979.2022.2062988.

DOI:10.1080/21655979.2022.2062988
PMID:35734878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9342252/
Abstract

ZNF503 antisense RNA 1 (ZNF503-AS1) is a newly identified long non-coding RNA (lncRNA) that regulates retinal pigment epithelium differentiation. To study its role in diabetic retinopathy, we performed RT-qPCR to measure plasma ZNF503-AS1 levels of 298 diabetic patients immediately after the diagnosis, during the follow-up, and at the end of follow-up. Plasma lncRNA ZNF503-AS1 expression in 96 healthy participants was also detected by RT-qPCR. Transforming growth factor beta 1 (TGF-β1) expression after ZNF503-AS1 overexpression was detected by Western blot. Cell proliferation and apoptosis were detected by cell proliferation and apoptosis assays, respectively. We found that ZNF503-AS1 was not differentially expressed in healthy participants and diabetic patients. High plasma lncRNA ZNF503-AS1 level was correlated with a high incidence of diabetic retinopathy. Plasma lncRNA ZNF503-AS1 level was higher in patients with diabetic retinopathy than in patients with other complications (p < 0.05). ZNF503-AS1 overexpression inhibited proliferation, promoted cell apoptosis, and upregulated TGF-β1 expression (p < 0.05). We concluded that ZNF503-AS1 might participate in diabetic retinopathy by activating TGF-β signaling.

摘要

锌指蛋白 503 反义 RNA1（ZNF503-AS1）是一种新鉴定的长非编码 RNA（lncRNA），可调节视网膜色素上皮细胞分化。为了研究其在糖尿病视网膜病变中的作用，我们通过 RT-qPCR 测量了 298 名糖尿病患者在诊断后、随访期间和随访结束时的血浆 ZNF503-AS1 水平，并检测了 96 名健康参与者的血浆 lncRNA ZNF503-AS1 表达。通过 Western blot 检测 ZNF503-AS1 过表达后转化生长因子β1（TGF-β1）的表达。通过细胞增殖和凋亡检测分别检测细胞增殖和凋亡。我们发现健康参与者和糖尿病患者之间 ZNF503-AS1 的表达没有差异。高血浆 lncRNA ZNF503-AS1 水平与糖尿病视网膜病变的高发生率相关。糖尿病视网膜病变患者的血浆 lncRNA ZNF503-AS1 水平高于其他并发症患者（p<0.05）。ZNF503-AS1 过表达抑制增殖，促进细胞凋亡，并上调 TGF-β1 表达（p<0.05）。我们得出结论，ZNF503-AS1 可能通过激活 TGF-β 信号通路参与糖尿病视网膜病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/f721b2fea38a/KBIE_A_2062988_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/30cda433f90a/KBIE_A_2062988_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/5bcfe7cd7b5f/KBIE_A_2062988_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/86eeeb2839b7/KBIE_A_2062988_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/bba28d1c55e4/KBIE_A_2062988_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/b1d84be9c114/KBIE_A_2062988_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/f721b2fea38a/KBIE_A_2062988_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/30cda433f90a/KBIE_A_2062988_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/5bcfe7cd7b5f/KBIE_A_2062988_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/86eeeb2839b7/KBIE_A_2062988_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/bba28d1c55e4/KBIE_A_2062988_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/b1d84be9c114/KBIE_A_2062988_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2410/9342252/f721b2fea38a/KBIE_A_2062988_F0005_OC.jpg

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4
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构建糖尿病皮下血管内皮细胞 lncRNA 相关 ceRNA 调控网络。
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