Ostovan Abbas, Arabi Maryam, Wang Yunqing, Li Jinhua, Li Bowei, Wang Xiaoyan, Chen Lingxin
CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Shandong Research Center for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003, China.
Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, 266071, China.
Adv Mater. 2022 Oct;34(42):e2203154. doi: 10.1002/adma.202203154. Epub 2022 Sep 20.
Molecular imprinting technology (MIT) produces artificial binding sites with precise complementarity to substrates and thereby is capable of exquisite molecular recognition. Over five decades of evolution, it is predicted that the resulting host imprinted materials will overtake natural receptors for research and application purposes, but in practice, this has not yet been realized due to the unsustainability of their life cycles (i.e., precursors, creation, use, recycling, and end-of-life). To address this issue, greenificated molecularly imprinted polymers (GMIPs) are a new class of plastic antibodies that have approached sustainability by following one or more of the greenification principles, while also demonstrating more far-reaching applications compared to their natural counterparts. In this review, the most recent developments in the delicate design and advanced application of GMIPs in six fast-growing and emerging fields are surveyed, namely biomedicine/therapy, catalysis, energy harvesting/storage, nanoparticle detection, gas sensing/adsorption, and environmental remediation. In addition, their distinct features are highlighted, and the optimal means to utilize these features for attaining incredibly far-reaching applications are discussed. Importantly, the obscure technical challenges of the greenificated MIT are revealed, and conceivable solutions are offered. Lastly, several perspectives on future research directions are proposed.
分子印迹技术（MIT）能产生与底物具有精确互补性的人工结合位点，因此具备卓越的分子识别能力。经过五十多年的发展，预计由此产生的主体印迹材料将在研究和应用方面超越天然受体，但实际上，由于其生命周期（即前体、制备、使用、回收和报废）的不可持续性，这一目标尚未实现。为解决这一问题，绿色化分子印迹聚合物（GMIPs）是一类新型的塑料抗体，它们通过遵循一项或多项绿色化原则实现了可持续性，同时与天然对应物相比，还展现出了更广泛的应用。在本综述中，我们调研了GMIPs在六个快速发展和新兴领域的精细设计和先进应用方面的最新进展，即生物医学/治疗、催化、能量收集/存储、纳米颗粒检测、气体传感/吸附和环境修复。此外，我们突出了它们的独特特征，并讨论了利用这些特征实现极其广泛应用的最佳方法。重要的是，揭示了绿色化MIT的模糊技术挑战，并提供了可行的解决方案。最后，提出了关于未来研究方向的几个观点。
