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使用分子印迹聚合物(MIPs)检测和消除小毒性分子

Small Toxic Molecule Detection and Elimination Using Molecularly Imprinted Polymers (MIPs).

作者信息

Kang Min Seok, Lee Jin-Ho, Kim Ki Su

机构信息

School of Chemical Engineering, Pusan National University, 2 Busandaehak-ro 63 Beon-gil, Geumjeong-gu, Busan 46241, Republic of Korea.

Department of Information Convergence Engineering, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, Republic of Korea.

出版信息

Biosensors (Basel). 2025 Jun 18;15(6):393. doi: 10.3390/bios15060393.

Abstract

Molecularly imprinted polymers (MIPs) provide selective, robust, and cost-effective platforms for the detection and removal of small toxic molecules in environmental, food, and biomedical contexts. This review offers a comprehensive overview of recent advancements in MIP-based systems, emphasizing critical design factors such as template selection, functional monomers, polymerization methods, and binding kinetics. The impact of these parameters on improving sensitivity, selectivity, and reusability is thoroughly examined. Additionally, current advantages, limitations, and enduring challenges are addressed. By highlighting emerging strategies and interdisciplinary innovations, this work aims to guide the development of more efficient and sustainable technologies for small-molecule toxin detection and remediation.

摘要

分子印迹聚合物(MIPs)为在环境、食品和生物医学领域检测和去除小毒性分子提供了选择性高、稳定性好且经济高效的平台。本综述全面概述了基于MIP的系统的最新进展,重点介绍了关键设计因素,如模板选择(template selection)、功能单体(functional monomers)、聚合方法(polymerization methods)和结合动力学(binding kinetics)。深入研究了这些参数对提高灵敏度、选择性和可重复使用性的影响。此外,还讨论了当前的优势、局限性和持久挑战。通过突出新兴策略和跨学科创新(interdisciplinary innovations),本研究旨在指导开发更高效、可持续的小分子毒素检测和修复技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14da/12190631/0066abf85b5e/biosensors-15-00393-g005.jpg

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