Atiba Ayman, Abdo Walied, Ali Ehab, Abd-Elsalam Marwa, Amer Mohamed, Abdel Monsef Ahmed, Taha Reda, Antar Samar, Mahmoud Ayman
Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
Department of Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
Biomarkers. 2022 Sep;27(6):608-617. doi: 10.1080/1354750X.2022.2085800. Epub 2022 Jun 29.
Burn injuries are underappreciated injuries that cause significant morbidity and mortality. Burn injuries, especially severe burns, trigger immunological and inflammatory responses, metabolic abnormalities, and distributive shock, all of which can be extended to multiple organ failures. () has been exploited for its medicinal properties for centuries. The goal of the present study is to examine the therapeutic effect of topical and oral administration of against deep second-degree burn in rats.
skin burn was created on the back of rats, and wound healing was assessed within the three examined groups; control, topical and oral throughout 30 days. Wound tissues were examined histologically, immunohistochemically for the expression of transforming growth factor beta-1 (TGF-β1), peroxiredoxin (Prdx6), and mRNA abundance of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) was assessed.
Our finding showed acceleration of wound contraction with both topical and oral administration. Maturation of granulation tissues was seen in both -supplemented groups. The topical application of revealed marked remodelling of the granulation tissues and higher expression levels of TGF-β1, VEGF, bFGF, and Prdx6 in comparison with control and oral groups ( < 0.001).
Both oral and topical applications of have beneficial effects in deep second-degree burn wound healing by boosting the growth factors and antioxidant status of skin tissue. The topical treatment was more efficient in accelerating wound healing and hence could be used efficiently to treat second-degree burns.
烧伤是一种未得到充分重视的损伤，会导致严重的发病率和死亡率。烧伤，尤其是重度烧伤，会引发免疫和炎症反应、代谢异常以及分布性休克，所有这些都可能发展为多器官功能衰竭。（）几个世纪以来一直因其药用特性而被利用。本研究的目的是考察局部和口服（）对大鼠深二度烧伤的治疗效果。
在大鼠背部造成皮肤烧伤，并在三个受试组中评估伤口愈合情况；对照组、局部应用（）组和口服（）组，为期30天。对伤口组织进行组织学检查、免疫组织化学检查以检测转化生长因子β-1（TGF-β1）、过氧化物氧还蛋白（Prdx6）的表达，并评估血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）的mRNA丰度。
我们的研究结果表明，局部和口服（）给药均能加速伤口收缩。在两个补充（）的组中均可见肉芽组织成熟。与对照组和口服（）组相比，局部应用（）显示肉芽组织有明显重塑，且TGF-β1、VEGF、bFGF和Prdx6的表达水平更高（<0.001）。
口服和局部应用（）均通过促进皮肤组织的生长因子和抗氧化状态，对深二度烧伤伤口愈合有有益作用。局部治疗在加速伤口愈合方面更有效，因此可有效用于治疗二度烧伤。
