State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
Biosensors (Basel). 2022 May 27;12(6):370. doi: 10.3390/bios12060370.
An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering to replicate the critical physiological environment and functions of the human organs. Therefore, it can be used to predict drug responses and environmental effects on organs. Microfluidic technology can control micro-scale reagents with high precision. Hence, microfluidics have been widely applied in organ-on-chip systems to mimic specific organ or multiple organs in vivo. These models integrated with various sensors show great potential in simulating the human environment. In this review, we mainly introduce the typical structures and recent research achievements of several organ-on-a-chip platforms. We also discuss innovations in models applied to the fields of pharmacokinetics/pharmacodynamics, nano-medicine, continuous dynamic monitoring in disease modeling, and their further applications in other fields.
器官芯片是一种将微制造和组织工程结合起来，以复制人体器官的关键生理环境和功能的装置。因此，它可以用于预测药物反应和环境对器官的影响。微流控技术可以高精度地控制微尺度试剂。因此，微流控技术已广泛应用于器官芯片系统，以模拟特定器官或多个体内器官。这些与各种传感器集成的模型在模拟人体环境方面显示出巨大的潜力。在这篇综述中，我们主要介绍了几种器官芯片平台的典型结构和最新研究成果。我们还讨论了在药代动力学/药效学、纳米医学、疾病建模中的连续动态监测等领域应用的模型的创新，以及它们在其他领域的进一步应用。
