Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering Health Science Center, Shenzhen University, Shenzhen 518055, China.
Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things, Guangdong and Hong Kong Joint Research Centre for Optical Fiber Sensors, Shenzhen University, Shenzhen 518060, China.
Biosensors (Basel). 2022 Jun 6;12(6):391. doi: 10.3390/bios12060391.
Blood glucose concentration is important for metabolic homeostasis in humans and animals. Many diabetic patients need to detect blood glucose daily which burdens community hospitals and family healthcare. Optical fiber sensors are widely used in biomedical detection because of their compact structure, fast response, high sensitivity, low cost, and ease of operation. In this work, we constructed a Fabry-Perot (FP) cavity biosensor for the fast detection of glucose concentration in serum. The femtosecond laser micromachining was applied to fabricate the FP cavity by printing the fiber-tip fixed-supported bridge at the end face of the optical fiber. An additional hemisphere was printed at the center of the outer surface of the bridge to avoid multi-beam interference. The results demonstrated that the proposed biosensor had high refractive index (RI) detection sensitivity, roughly 1039 nm/RIU at a wavelength of 1590 nm, and the detection sensitivity for glucose was around 0.185 nm/ (mg/mL) at a wavelength of 1590 nm. Due to its high sensitivity, compact structure, and fast response, the FP cavity biosensor has great potential to be applied in family healthcare for glucose concentration detection of diabetic patients.
血糖浓度对人类和动物的代谢稳态很重要。许多糖尿病患者需要每天检测血糖，这给社区医院和家庭医疗带来了负担。光纤传感器由于其结构紧凑、响应速度快、灵敏度高、成本低、易于操作等优点，在生物医学检测中得到了广泛的应用。在这项工作中，我们构建了一种用于快速检测血清中葡萄糖浓度的法布里-珀罗（FP）腔生物传感器。飞秒激光微加工技术通过在光纤端面打印光纤尖端固定支撑桥来制造 FP 腔。在桥的外表面中心打印一个附加的半球，以避免多光束干涉。结果表明，所提出的生物传感器具有较高的折射率（RI）检测灵敏度，在 1590nm 波长下约为 1039nm/RIU，在 1590nm 波长下对葡萄糖的检测灵敏度约为 0.185nm/（mg/mL）。由于其高灵敏度、结构紧凑和快速响应，FP 腔生物传感器在家庭医疗中用于检测糖尿病患者的血糖浓度具有很大的应用潜力。
