College of Information Science and Technology, Dalian Maritime University, Dalian, 116026, China.
Analyst. 2020 Mar 2;145(5):1605-1628. doi: 10.1039/c9an01998g.
Optical biosensors have exhibited worthwhile performance in detecting biological systems and promoting significant advances in clinical diagnostics, drug discovery, food process control, and environmental monitoring. Without complexity in their pretreatment and probable influence on the nature of target molecules, these biosensors have additional advantages such as high sensitivity, robustness, reliability, and potential to be integrated on a single chip. In this review, the state of the art optical biosensor technologies, including those based on surface plasmon resonance (SPR), optical waveguides, optical resonators, photonic crystals, and optical fibers, are presented. The principles for each type of biosensor are concisely introduced and particular emphasis has been placed on recent achievements. The strengths and weaknesses of each type of biosensor have been outlined as well. Concluding remarks regarding the perspectives of future developments are discussed.
光学生物传感器在检测生物系统方面表现出了有价值的性能，并在临床诊断、药物发现、食品加工控制和环境监测方面取得了重大进展。由于其预处理简单，且对目标分子的性质可能没有影响，这些生物传感器具有高灵敏度、高稳定性、高可靠性和集成在单个芯片上的潜力等额外优势。在本文中，介绍了包括基于表面等离子体共振（SPR）、光波导、光谐振器、光子晶体和光纤的先进光学生物传感器技术。简要介绍了每种生物传感器的原理，并特别强调了最新的研究进展。概述了每种生物传感器的优缺点。最后还讨论了未来发展的前景。
