Nawaz Asif, Farid Arshad, Safdar Muhammad, Latif Muhammad Shahid, Ghazanfar Shakira, Akhtar Nosheen, Al Jaouni Soad K, Selim Samy, Khan Muhammad Waseem
Advanced Drug Delivery Lab, Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan 29050, Pakistan.
Gomal Center of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan 29050, Pakistan.
Gels. 2022 Jun 16;8(6):384. doi: 10.3390/gels8060384.
The aim of the present research was to formulate and evaluate curcumin hydrogel and to investigate the potential of natural essential oils as permeation enhancers.
Curcumin 2% / hydrogel containing various concentrations of eucalyptus oil, aloe vera oil and clove oil was developed using carboxy methyl cellulose (CMC) as a gelling agent. Differential scanning calorimetry and Fourier Transform infrared spectroscopy were used to evaluate the compatibility between the drug and the excipients. In order to assess the efficacy of the formulation; rheological properties, skin irritation studies, in vitro release, ex vivo permeation and retention studies were conducted.
DSC and FTIR suggest no in-compatibility between curcumin and excipients. Studies proved that addition of suitable natural permeation enhancers to the hydrogels improved the in vitro release and ex vivo permeation and retention of curcumin. From the various natural essential oils, the aloe vera oil at a concentration of 3% / had the greatest effect on the permeability rate and skin retention of the Curcumin and produces the highest enhancement ratio amongst all the concentrations of essential oils examined.
Aloe vera oil enhances the permeation of curcumin across the skin by altering the complex structure of the stratum corneum without itself undergoing any change. The developed curcumin hydrogels along with natural essential oils may present an effective choice regarding skin infection/wound healing.
本研究的目的是制备并评估姜黄素水凝胶，并研究天然精油作为渗透促进剂的潜力。
以羧甲基纤维素（CMC）作为胶凝剂，制备含2%姜黄素以及不同浓度桉叶油、芦荟油和丁香油的水凝胶。采用差示扫描量热法和傅里叶变换红外光谱法评估药物与辅料之间的相容性。为了评估该制剂的疗效，进行了流变学性质、皮肤刺激性研究、体外释放、离体渗透和滞留研究。
差示扫描量热法和傅里叶变换红外光谱法表明姜黄素与辅料之间不存在不相容性。研究证明，向水凝胶中添加合适的天然渗透促进剂可改善姜黄素的体外释放、离体渗透和滞留。在各种天然精油中，3%浓度的芦荟油对姜黄素的渗透率和皮肤滞留效果最佳，在所检测的所有精油浓度中产生的增强率最高。
芦荟油通过改变角质层的复杂结构而自身不发生任何变化来增强姜黄素经皮渗透。所制备的姜黄素水凝胶与天然精油一起可能是皮肤感染/伤口愈合方面的有效选择。
