LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Mar Drugs. 2022 May 25;20(6):347. doi: 10.3390/md20060347.
Marine life has proved to be an invaluable source of new compounds with significant bioactivities, such as xanthones. This review summarizes the advances made in the study of marine-derived xanthones from 2010 to 2021, from isolation towards synthesis, highlighting their biological activities. Most of these compounds were isolated from marine-derived fungi, found in marine sediments, and associated with other aquatic organisms (sponge and jellyfish). Once isolated, xanthones have been assessed for different bioactivities, such as antibacterial, antifungal, and cytotoxic properties. In the latter case, promising results have been demonstrated. Considering the significant bioactivities showed by xanthones, efforts have been made to synthesize these compounds, like yicathins B and C and the secalonic acid D, through total synthesis.
海洋生物已被证明是具有重要生物活性的新型化合物的宝贵来源，如黄烷酮。本综述总结了 2010 年至 2021 年海洋来源的黄烷酮在分离到合成方面的研究进展，强调了它们的生物活性。这些化合物大多是从海洋来源的真菌中分离出来的，这些真菌存在于海洋沉积物中，并与其他水生生物（海绵和水母）有关。一旦被分离出来，黄烷酮就被评估了不同的生物活性，如抗菌、抗真菌和细胞毒性。在后一种情况下，已经证明了有希望的结果。考虑到黄烷酮表现出的显著生物活性，人们已经努力通过全合成来合成这些化合物，如 yicathins B 和 C 以及 secalonic 酸 D。
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