aspergixanthones I-K，新型海洋来源真菌 sp. ZA-01 来源的抗异戊烯基黄烷酮。
Aspergixanthones I⁻K, New Anti- Prenylxanthones from the Marine-Derived Fungus sp. ZA-01.
机构信息
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
Shandong Provincial Key Laboratory of Synthetic Biology, CAS Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
出版信息
Mar Drugs. 2018 Sep 4;16(9):312. doi: 10.3390/md16090312.
Marine-derived fungi are a rich source of structurally diverse metabolites. Fungi produce an array of compounds when grown under different cultivation conditions. In the present work, different media were used to cultivate the fungus sp. ZA-01, which was previously studied for the production of bioactive compounds, and three new prenylxanthone derivatives, aspergixanthones I⁻K (⁻), and four known analogues (⁻) were obtained. The absolute configuration of was assigned by ECD experiment and the Mo₂(AcO)₄ ICD spectrum of its methanolysis derivative (). All the compounds (⁻) were evaluated for their anti- activities. Aspergixanthone I () showed the strongest anti- activity against (MIC = 1.56 μM), (MIC = 1.56 μM), and (MIC = 3.12 μM).
海洋来源的真菌是结构多样代谢产物的丰富来源。当在不同的培养条件下生长时，真菌会产生一系列化合物。在本工作中，使用不同的培养基来培养先前研究过生物活性化合物生产的真菌 sp. ZA-01，得到了三个新的倍半萜黄烷酮衍生物 Aspergixanthones I⁻K（⁻）和四个已知类似物（⁻）。通过 ECD 实验和甲醇解衍生物（）的 Mo₂(AcO)₄ ICD 光谱确定了 的绝对构型。所有化合物（⁻）均评估了其抗活性。Aspergixanthone I（）对 （MIC = 1.56 μM）、 （MIC = 1.56 μM）和 （MIC = 3.12 μM）表现出最强的抗活性。
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