Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Nat Prod Res. 2022 Oct;36(19):4982-4989. doi: 10.1080/14786419.2021.1915309. Epub 2021 Apr 27.
Four new aromatic polyketides including two diphenyl ethers (pseudopithoethers A-B, -), one benzofuranone (pseudopithonone, ) and one xanthone (pseudopithoxanthone, ), along with two known compounds (-) and one new naturally occurring hydroquinone (α,2,5-trihydroxyacetophenone, ) were isolated from the marine-derived fungus PSU-AMF350. Their structures were identified by analysis of spectroscopic data. All isolated compounds were tested for antimicrobial activity. Only compound displayed antibacterial activity against methicillin-resistant with the MIC value of 128 g/mL and against , NPRC005 and NPRC007 with the same MIC value of 200 g/mL.[Formula: see text].
从海洋来源真菌 PSU-AMF350 中分离得到四个新的芳香聚酮类化合物，包括两个二苯醚（伪皮托醚 A-B，-）、一个苯并呋喃酮（伪皮托酮，）和一个黄烷酮（伪皮托黄烷酮，），以及两个已知化合物（-）和一个新的天然对苯二酚（α，2,5-三羟基苯乙酮，）。通过光谱数据分析鉴定了它们的结构。所有分离得到的化合物都进行了抗菌活性测试。只有化合物 对耐甲氧西林金黄色葡萄球菌（MRSA）具有抗菌活性，MIC 值为 128μg/mL，对 、NPRC005 和 NPRC007 的 MIC 值相同，均为 200μg/mL。
