Wildfeuer A, Dopfer R, Niethammer D, Galle J, Laufen H, Haferkamp O, Vanek E
Klin Wochenschr. 1987 Feb 2;65(3):113-20. doi: 10.1007/BF01728602.
Different strains of Bacteroides fragilis exhibit great differences in sensitivity towards serum from healthy volunteers. In the presence of 10% autologous serum, neutrophilic granulocytes and monocytes (macrophages) caused significant killing of B. fragilis. The measured phagocytic and killing activity of the cells is comparable to their activity against aerobic bacteria (S. aureus). In four patients with chronic granulomatous disease of childhood, phagocytosis was normal but killing of B. fragilis and S. aureus in granulocytes or monocytes (macrophages) was appreciably lowered. This malfunction of the cells was accompanied by a disturbance in oxidative metabolism and inadequate iodination after phagocytosis of B. fragilis. The results suggest that granulocytes and monocytes play an important role in host defense against endogenous infections with anaerobes.
不同菌株的脆弱拟杆菌对健康志愿者血清的敏感性存在很大差异。在10%自体血清存在的情况下，中性粒细胞和单核细胞（巨噬细胞）可导致脆弱拟杆菌大量死亡。所测细胞的吞噬和杀伤活性与其对需氧菌（金黄色葡萄球菌）的活性相当。在4例儿童慢性肉芽肿病患者中，吞噬作用正常，但粒细胞或单核细胞（巨噬细胞）对脆弱拟杆菌和金黄色葡萄球菌的杀伤作用明显降低。细胞的这种功能障碍伴随着氧化代谢紊乱以及吞噬脆弱拟杆菌后碘化不足。结果表明，粒细胞和单核细胞在宿主抵御厌氧菌内源性感染中发挥重要作用。
