在小鼠研究中拥抱自然病毒的异质性。
Embracing the heterogeneity of natural viruses in mouse studies.
机构信息
Department of Microbiology and Immunology and the Center for Immunology, University of Minnesota, Minneapolis, USA.
出版信息
J Gen Virol. 2022 Jun;103(6). doi: 10.1099/jgv.0.001758.
Abstract
Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to incorporate a natural microbiota to laboratory mouse models and the impacts the microbiota has on immune responses, with a focus on viruses.
摘要
动物模型是现代生物学的重要工具。为了提高可重复性和减少混杂变量，现代动物模型排除了许多微生物，包括关键的天然共生菌和病原体。在这里，我们讨论了最近将天然微生物群纳入实验室小鼠模型的策略，以及微生物群对免疫反应的影响，重点是病毒。
相似文献
1
Embracing the heterogeneity of natural viruses in mouse studies.在小鼠研究中拥抱自然病毒的异质性。
J Gen Virol. 2022 Jun;103(6). doi: 10.1099/jgv.0.001758.
2
Expanding the role of the virome: commensalism in the gut.拓展病毒组的作用：肠道中的共生关系
J Virol. 2015 Feb;89(4):1951-3. doi: 10.1128/JVI.02966-14. Epub 2014 Dec 10.
3
Embracing microbial exposure in mouse research.在小鼠研究中拥抱微生物暴露。
J Leukoc Biol. 2019 Jan;105(1):73-79. doi: 10.1002/JLB.4RI0718-273R. Epub 2018 Sep 27.
4
Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome.肠病毒引起广泛的宿主免疫反应，类似于细菌微生物组引起的反应。
Cell Host Microbe. 2021 Jun 9;29(6):1014-1029.e8. doi: 10.1016/j.chom.2021.03.015. Epub 2021 Apr 23.
5
Laboratory mice born to wild mice have natural microbiota and model human immune responses.从野生鼠类中出生的实验鼠拥有天然微生物菌群，并可模拟人类的免疫反应。
Science. 2019 Aug 2;365(6452). doi: 10.1126/science.aaw4361. Epub 2019 Aug 1.
6
Diet, microbiota and autoimmune diseases.饮食、微生物群与自身免疫性疾病。
Lupus. 2014 May;23(6):518-26. doi: 10.1177/0961203313501401.
7
Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility.人工微生物组异质性激发了六个实用的行动主题和示例，以提高研究动力驱动的可重复性。
Sci Rep. 2020 Mar 19;10(1):5039. doi: 10.1038/s41598-020-60900-y.
8
Causative Microbes in Host-Microbiome Interactions.宿主-微生物组相互作用中的致病微生物。
Annu Rev Microbiol. 2021 Oct 8;75:223-242. doi: 10.1146/annurev-micro-041321-042402. Epub 2021 Aug 4.
9
Gut Virome: Role and Distribution in Health and Gastrointestinal Diseases.肠道病毒组：在健康和胃肠道疾病中的作用和分布。
Front Cell Infect Microbiol. 2022 Mar 10;12:836706. doi: 10.3389/fcimb.2022.836706. eCollection 2022.
10
The Skin Microbiota: Balancing Risk and Reward.皮肤微生物群：平衡风险与收益。
Cell Host Microbe. 2020 Aug 12;28(2):190-200. doi: 10.1016/j.chom.2020.06.017.
引用本文的文献
1
Sequential early-life viral infections modulate the microbiota and adaptive immune responses to systemic and mucosal vaccination.序贯性早期生命病毒感染可调节微生物组和适应性免疫应答，以实现全身性和黏膜性疫苗接种。
PLoS Pathog. 2024 Oct 2;20(10):e1012557. doi: 10.1371/journal.ppat.1012557. eCollection 2024 Oct.
2
A comparison of short-read, HiFi long-read, and hybrid strategies for genome-resolved metagenomics.短读、HiFi 长读和混合策略在基因组解析宏基因组学中的比较。
Microbiol Spectr. 2024 Apr 2;12(4):e0359023. doi: 10.1128/spectrum.03590-23. Epub 2024 Mar 7.
3
Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination.微生物暴露史的小鼠模型比较揭示了微生物多样性和疫苗接种反应的差异。
mSphere. 2024 Feb 28;9(2):e0065423. doi: 10.1128/msphere.00654-23. Epub 2024 Jan 29.
4
Into the wild: How exposure to wild or domesticated fungi shapes immune responses in mice.回归自然：接触野生或家养真菌如何塑造小鼠的免疫反应。
PLoS Pathog. 2022 Oct 13;18(10):e1010841. doi: 10.1371/journal.ppat.1010841. eCollection 2022 Oct.
本文引用的文献
1
Oncogenic Viruses as Entropic Drivers of Cancer Evolution.致癌病毒作为癌症进化的熵驱动因素
Front Virol. 2021 Nov;1. doi: 10.3389/fviro.2021.753366. Epub 2021 Nov 15.
2
Natural rodent model of viral transmission reveals biological features of virus population dynamics.自然啮齿动物病毒传播模型揭示病毒群体动力学的生物学特征。
J Exp Med. 2022 Feb 7;219(2). doi: 10.1084/jem.20211220. Epub 2021 Dec 27.
3
Enteric virome negatively affects seroconversion following oral rotavirus vaccination in a longitudinally sampled cohort of Ghanaian infants.肠道病毒组对加纳婴儿纵向采样队列中口服轮状病毒疫苗接种后的血清转化率产生负面影响。
Cell Host Microbe. 2022 Jan 12;30(1):110-123.e5. doi: 10.1016/j.chom.2021.12.002. Epub 2021 Dec 20.
4
Mice with diverse microbial exposure histories as a model for preclinical vaccine testing.具有不同微生物暴露史的小鼠作为临床前疫苗测试的模型。
Cell Host Microbe. 2021 Dec 8;29(12):1815-1827.e6. doi: 10.1016/j.chom.2021.10.001. Epub 2021 Nov 2.
5
Characterization of the Eukaryotic Virome of Mice from Different Sources.不同来源小鼠真核病毒组的特征分析
Microorganisms. 2021 Sep 30;9(10):2064. doi: 10.3390/microorganisms9102064.
6
Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome.肠病毒引起广泛的宿主免疫反应，类似于细菌微生物组引起的反应。
Cell Host Microbe. 2021 Jun 9;29(6):1014-1029.e8. doi: 10.1016/j.chom.2021.03.015. Epub 2021 Apr 23.
7
Expansible residence decentralizes immune homeostasis.可扩张住宅使免疫稳态去中心化。
Nature. 2021 Apr;592(7854):457-462. doi: 10.1038/s41586-021-03351-3. Epub 2021 Mar 17.
8
Generating Mice with Diverse Microbial Experience.生成具有不同微生物体验的小鼠。
Curr Protoc. 2021 Feb;1(2):e53. doi: 10.1002/cpz1.53.
9
A Model System for Feralizing Laboratory Mice in Large Farmyard-Like Pens.在类似大农场围栏中将实验小鼠野化的模型系统。
Front Microbiol. 2021 Jan 11;11:615661. doi: 10.3389/fmicb.2020.615661. eCollection 2020.
10
Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity.多微生物脓毒症损害抗原特异性记忆 CD4 T 细胞介导的免疫。
Front Immunol. 2020 Aug 12;11:1786. doi: 10.3389/fimmu.2020.01786. eCollection 2020.
Zotero 插件