Viroel Fabia Judice Marques, Laurino Leticia Favara, Caetano Érika Leão Ajala, Jozala Angela Faustino, Spim Sara Rosicler Vieira, Pickler Thaisa Borim, Sercundes Michelle Klein, Gomes Marcela C, Hataka Alessandre, Grotto Denise, Gerenutti Marli
Department of Pharmacy, University of Sorocaba, Sorocaba 18023-000, Brazil.
Department of Veterinary Clinical Sciences, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu 18610-307, Brazil.
Antioxidants (Basel). 2022 May 24;11(6):1035. doi: 10.3390/antiox11061035.
The consumption of functional foods, such as mushrooms, apparently influences Gestational Diabetes Mellitus (GDM), and brings benefits to maternal-fetal health. contains a variety of bioactive compounds, such as polysaccharides, proteins and polyphenols that are able to control blood glucose and be used in anti-cancer therapy. We aimed to evaluate the effects of the consumption of (Gl) on maternal-fetal outcomes in streptozotocin-induced GDM (GDM-STZ). Pregnant rats were exposed to Gl (100 mg/kg/day) before and after the induction of GDM-STZ (single dose 40 mg/kg) on the eighth pregnancy day. Biochemical and oxidative stress parameters, reproductive performance and morphometry of fetuses were assessed. Gl reduced the glycemic response in the oral glucose tolerance test. Moreover, Gl decreased AST and ALT activities. GDM increased lipid peroxidation, which was reverted by Gl. Catalase and glutathione peroxidase activities were decreased in GDM and the administered Gl after the fetus implantation increased catalase activity. Measurements of the fetal head, thorax, craniocaudal and tail showed greater values in fetuses from rats exposed to Gl compared to GDM. has an encouraging nutritional and medicinal potential against GDM, since it modifies glucose metabolism, reduces lipid peroxidation, and has protective effects in fetuses born from GDM dams.
食用功能性食品，如蘑菇，显然会影响妊娠期糖尿病（GDM），并对母婴健康有益。蘑菇含有多种生物活性化合物，如多糖、蛋白质和多酚，这些物质能够控制血糖并用于抗癌治疗。我们旨在评估食用蘑菇提取物（Gl）对链脲佐菌素诱导的妊娠期糖尿病（GDM-STZ）母婴结局的影响。在妊娠第8天诱导GDM-STZ（单剂量40mg/kg）之前和之后，将怀孕大鼠暴露于Gl（100mg/kg/天）。评估了生化和氧化应激参数、生殖性能以及胎儿的形态学指标。Gl降低了口服葡萄糖耐量试验中的血糖反应。此外，Gl降低了谷草转氨酶（AST）和谷丙转氨酶（ALT）的活性。GDM增加了脂质过氧化，而Gl可使其恢复。GDM中过氧化氢酶和谷胱甘肽过氧化物酶的活性降低，而在胎儿植入后给予Gl可增加过氧化氢酶的活性。与GDM组相比，对暴露于Gl的大鼠所产胎儿的头部、胸部、头尾和尾巴的测量显示出更大的值。蘑菇提取物对GDM具有令人鼓舞的营养和药用潜力，因为它可改善葡萄糖代谢、减少脂质过氧化，并对GDM母鼠所生胎儿具有保护作用。
