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永生花（蒙奇）作为抗高血压药物的潜在作用：对大鼠主动脉的血管舒张作用。

The Potential Role of Everlasting Flower ( Moench) as an Antihypertensive Agent: Vasorelaxant Effects in the Rat Aorta.

作者信息

Valero Marta Sofía, Nuñez Sonia, Les Francisco, Castro Marta, Gómez-Rincón Carlota, Arruebo María Pilar, Plaza Miguel Ángel, Köhler Ralf, López Víctor

机构信息

Departamento de Farmacología, Fisiología y Medicina Legal y Forense, Universidad de Zaragoza, 50009 Zaragoza, Spain.

Instituto Agroalimentario de Aragón, IA2, Universidad de Zaragoza-CITA, 50830 Zaragoza, Spain.

出版信息

Antioxidants (Basel). 2022 May 31;11(6):1092. doi: 10.3390/antiox11061092.

DOI:10.3390/antiox11061092
PMID:35739989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9219724/
Abstract

Helichrysum stoechas (L.) Moench (H. stoechas) is a medicinal plant traditionally used in the Iberian Peninsula to treat different disorders such as arterial hypertension. The aim of this study was to investigate the vascular effects of a polyphenolic methanolic extract of H. stoechas, which has high antioxidant activity, and its mechanism of action. Isometric myography studies were performed in an organ bath with rat aortic rings with intact endothelium. The H. stoechas extract produced vasorelaxation in the aortic rings that were precontracted by phenylephrine or KCl. L-NAME and Rp-8-Br-PET-cGMPS but not indomethacin or H-89; it also reduced the relaxant response evoked by H. stoechas extract on the phenylephrine-induced contractions. H. stoechas extract reduced the response to CaCl2 similar to verapamil and reduced the phenylephrine-induced contractions comparable with heparin. TRAM-34, apamin and glibenclamide reduced relaxation induced by the H. stoechas extract. The combination of L-NAME+TRAM-34+apamin almost completely inhibited the H. stoechas-induced effect. In conclusion, the relaxant effect of the H. stoechas extract is partially mediated by endothelium through the activation of the NO/PKG/cGMP pathway and the opening of Ca2+-activated K+ channels. Furthermore, the decrease in the cytosolic Ca2+ by the inhibition of Ca2+ influx through the L-type Ca2+ channels and by the reduction of Ca2+ release from the sarcoplasmic reticulum via the IP3 pathway is also involved.

摘要

蜡菊（Helichrysum stoechas (L.) Moench，简称H. stoechas）是一种药用植物，在伊比利亚半岛传统上用于治疗多种疾病，如动脉高血压。本研究旨在探究具有高抗氧化活性的蜡菊多酚甲醇提取物的血管效应及其作用机制。在器官浴中对具有完整内皮的大鼠主动脉环进行等长肌电图研究。蜡菊提取物可使由去氧肾上腺素或氯化钾预收缩的主动脉环产生血管舒张。L-NAME和Rp-8-Br-PET-cGMPS可产生此作用，但吲哚美辛或H-89则不能；它还降低了蜡菊提取物对去氧肾上腺素诱导收缩的舒张反应。蜡菊提取物降低对氯化钙的反应，类似于维拉帕米，并降低与肝素相当的去氧肾上腺素诱导的收缩。TRAM-34、蜂毒明肽和格列本脲可降低蜡菊提取物诱导的舒张。L-NAME + TRAM-34 + 蜂毒明肽的组合几乎完全抑制了蜡菊提取物的作用。总之，蜡菊提取物的舒张作用部分由内皮通过激活NO/PKG/cGMP途径和打开钙激活钾通道介导。此外，通过抑制L型钙通道的钙内流以及通过IP3途径减少肌浆网的钙释放来降低胞质钙也参与其中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f476/9219724/393c7097c05e/antioxidants-11-01092-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f476/9219724/0b507c072002/antioxidants-11-01092-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f476/9219724/2a4641b1ca6d/antioxidants-11-01092-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f476/9219724/393c7097c05e/antioxidants-11-01092-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f476/9219724/ee5de3800d48/antioxidants-11-01092-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f476/9219724/50ba19ca3137/antioxidants-11-01092-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f476/9219724/0b507c072002/antioxidants-11-01092-g006.jpg
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