School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Oxid Med Cell Longev. 2021 Jun 25;2021:5471347. doi: 10.1155/2021/5471347. eCollection 2021.
Stroke is the second most common cause of death globally and the leading cause of death in China. The pathogenesis of cerebral ischemia injury is complex, and oxidative stress plays an important role in the fundamental pathologic progression of cerebral damage in ischemic stroke. Previous studies have preliminarily confirmed that oxidative stress should be a potential therapeutic target and antioxidant as a treatment strategy for ischemic stroke. Emerging experimental studies have demonstrated that polyphenols exert the antioxidant potential to play the neuroprotection role after ischemic stroke. This comprehensive review summarizes antioxidant effects of some polyphenols, which have the most inhibition effects on reactive oxygen species generation and oxidative stress after ischemic stroke.
脑卒中是全球范围内第二大致死原因，也是中国的首要致死病因。脑缺血损伤的发病机制复杂，氧化应激在缺血性脑卒中脑损伤的基本病理进展中发挥重要作用。既往研究初步证实，氧化应激应是潜在的治疗靶点，抗氧化剂是缺血性脑卒中的治疗策略。新兴的实验研究表明，多酚类物质发挥抗氧化潜能，在缺血性脑卒中后发挥神经保护作用。本综述总结了一些多酚类物质的抗氧化作用，这些多酚类物质对缺血性脑卒中后活性氧生成和氧化应激的抑制作用最强。
