Da Broi Michele Gomes, Ferreira Elisa Melo, Andrade Aline Zyman, Jordão Alceu Afonso, Ferriani Rui Alberto, Navarro Paula Andrea
Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14048-900, SP, Brazil.
National Institute of Hormones and Women's Health, CNPq-Conselho Nacional de Desenvolvimento Científico e Tecnológico, Porto Alegre 90035-003, RS, Brazil.
Antioxidants (Basel). 2022 Jun 14;11(6):1161. doi: 10.3390/antiox11061161.
Endometriosis-related infertility is associated with oxidative stress (OS). The present study aims to compare serum OS markers of infertile women with endometriosis and controls during the follicular phase of the natural cycle (D1), after pituitary downregulation using a GnRH agonist (D2), after controlled ovarian stimulation (COS) on the day of human chorionic gonadotropin administration (D3), and on the day of oocyte retrieval (D4). One hundred and eight serum samples (58 controls and 35 early and 18 advanced endometriosis cases) were collected at these four timepoints. OS markers were compared among the groups and timepoints using a linear regression model with mixed effects and a post-test using orthogonal contrasts. The significance was set at 5%. We observed altered OS markers in the endometriosis patients during the D1, D2, D3, and D4 timepoints compared to the controls. The evidence of systemic OS in infertile patients with endometriosis during COS suggests the mobilization of potent antioxidants in an attempt to protect the oocyte from oxidative damage, especially on the day of oocyte retrieval.
子宫内膜异位症相关的不孕症与氧化应激（OS）有关。本研究旨在比较自然周期卵泡期（D1）、使用促性腺激素释放激素激动剂进行垂体降调节后（D2）、人绒毛膜促性腺激素给药当天控制性卵巢刺激（COS）后（D3）以及取卵当天（D4），患有子宫内膜异位症的不孕女性与对照组的血清OS标志物。在这四个时间点收集了108份血清样本（58名对照组、35名早期和18名晚期子宫内膜异位症病例）。使用具有混合效应的线性回归模型和使用正交对比的事后检验比较组间和时间点的OS标志物。显著性设定为5%。我们观察到，与对照组相比，子宫内膜异位症患者在D1、D2、D3和D4时间点的OS标志物发生了改变。COS期间患有子宫内膜异位症的不孕患者存在全身OS的证据表明，机体调动了强效抗氧化剂，试图保护卵母细胞免受氧化损伤，尤其是在取卵当天。
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