Zhao Liang, Wang Shaoxuan, Zhang Nanhai, Zhou Jingxuan, Mehmood Arshad, Raka Rifat Nowshin, Zhou Feng, Zhao Lei
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Antioxidants (Basel). 2022 Jun 20;11(6):1211. doi: 10.3390/antiox11061211.
Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. It can cause fatty liver (steatosis), steatohepatitis, fibrosis, cirrhosis, and liver cancer. Alcohol consumption can also disturb the composition of gut microbiota, increasing the composition of harmful microbes and decreasing beneficial ones. Restoring eubiosis or preventing dysbiosis after alcohol consumption is an important strategy in treating ALD. Plant natural products and polyphenolic compounds exert beneficial effects on several metabolic disorders associated with ALD. Natural products and related phytochemicals act through multiple pathways, such as modulating gut microbiota, improving redox stress, and anti-inflammation. In the present review article, we gather information on natural extract and bioactive compounds on the gut-liver axis for the possible treatment of ALD. Supplementation with natural extracts and bioactive compounds promoted the intestinal tight junction, protected against the alcohol-induced gut leakiness and inflammation, and reduced endotoxemia in alcohol-exposed animals. Taken together, natural extracts and bioactive compounds have strong potential against ALD; however, further clinical studies are still needed.
酒精性肝病（ALD）是全球发病和死亡的主要原因。它可导致脂肪肝（脂肪变性）、脂肪性肝炎、纤维化、肝硬化和肝癌。饮酒还会扰乱肠道微生物群的组成，增加有害微生物的比例，减少有益微生物。恢复饮酒后的微生态平衡或预防生态失调是治疗ALD的重要策略。植物天然产物和多酚类化合物对与ALD相关的几种代谢紊乱具有有益作用。天然产物和相关植物化学物质通过多种途径发挥作用，如调节肠道微生物群、改善氧化还原应激和抗炎。在本综述文章中，我们收集了关于天然提取物和生物活性化合物在肠-肝轴上可能治疗ALD的信息。补充天然提取物和生物活性化合物可促进肠道紧密连接，防止酒精诱导的肠道渗漏和炎症，并降低酒精暴露动物的内毒素血症。综上所述，天然提取物和生物活性化合物对ALD具有强大的治疗潜力；然而，仍需要进一步的临床研究。
