Li Bangyan, Mao Qianqian, Zhou Dandan, Luo Min, Gan Renyou, Li Hangyu, Huang Siyu, Saimaiti Adila, Shang Ao, Li Huabin
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.
Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu 610213, China.
Foods. 2021 May 28;10(6):1232. doi: 10.3390/foods10061232.
Gut microbiota dysbiosis has been a crucial contributor to the pathogenesis of alcoholic fatty liver disease (AFLD). Tea is a popular beverage worldwide and exerts antioxidant and anti-inflammatory activities, as well as hepatoprotective effects. However, the potential role of gut microbiota regulated by tea in the prevention and management of AFLD remains unclear. Here, the protective effects of oolong tea, black tea, and dark tea on AFLD and its regulation of gut microbiota in chronic alcohol-exposed mice were explored and investigated. The results revealed that tea supplementation significantly prevented liver steatosis, decreased oxidative stress and inflammation, and modulated gut microbiota in chronic alcohol-exposed mice, especially oolong tea and dark tea. However, black tea showed less effectiveness against liver injury caused by alcohol. Moreover, the diversity, structure and composition of chronic alcohol-disrupted gut microbiota were restored by the supplementation of oolong tea and dark tea based on the analysis of gut microbiota. Furthermore, the relationship between liver injury biochemical indicators and gut microbiota indicated that some specific bacteria, such as , , and were closely associated with AFLD. In addition, the phytochemical components in tea extracts were measured by high-performance liquid chromatography, which could contribute to preventive effects on AFLD. In summary, oolong tea and dark tea could prevent chronic alcohol exposure-induced AFLD by modulating gut microbiota.
肠道微生物群失调一直是酒精性脂肪肝病（AFLD）发病机制的关键因素。茶是全球流行的饮品，具有抗氧化、抗炎活性以及肝脏保护作用。然而，茶对肠道微生物群的调节作用在AFLD预防和管理中的潜在作用仍不清楚。在此，研究了乌龙茶、红茶和黑茶对AFLD的保护作用及其对慢性酒精暴露小鼠肠道微生物群的调节作用。结果表明，补充茶显著预防了慢性酒精暴露小鼠的肝脏脂肪变性，降低了氧化应激和炎症，并调节了肠道微生物群，尤其是乌龙茶和黑茶。然而，红茶对酒精引起的肝损伤效果较差。此外，基于肠道微生物群分析，补充乌龙茶和黑茶可恢复慢性酒精破坏的肠道微生物群的多样性、结构和组成。此外，肝脏损伤生化指标与肠道微生物群之间的关系表明，一些特定细菌，如 、 和 与AFLD密切相关。此外，通过高效液相色谱法测定了茶提取物中的植物化学成分，这些成分可能有助于对AFLD的预防作用。总之，乌龙茶和黑茶可通过调节肠道微生物群预防慢性酒精暴露诱导的AFLD。
