Marcoux Diane, Etienne Isabelle, Van Muylem Alain, Bogossian Elisa Gouvea, Yin Nicolas, Taccone Fabio Silvio, Hites Maya
Clinic of Infectious Diseases, HUB-Erasme Hospital, 1070 Brussels, Belgium.
Department of Pneumology, HUB-Erasme Hospital, 1070 Brussels, Belgium.
Antibiotics (Basel). 2022 May 24;11(6):704. doi: 10.3390/antibiotics11060704.
Few data are available on infectious complications in critically ill patients with different viral infections. We performed a retrospective monocentric study including all of the patients admitted to the intensive care unit (ICU) with confirmed COVID-19 (as of 13 March 2020) or Influenza A and/or B infections (as of 1 January 2015) until 20 April 2020. Coinfection and secondary infections (occurring within and after 48 h from admission, respectively) were recorded. Fifty-seven COVID-19 and 55 Influenza patients were included. Co-infections were documented in 13/57 (23%) COVID-19 patients vs. 40/55 (73%) Influenza patients (p < 0.001), most of them being respiratory (9/13, 69% vs. 35/40, 88%; p = 0.13) and of bacterial origin (12/13, 92% vs. 29/40, 73%; p = 0.25). Invasive aspergillosis infections were observed only in Influenza patients (8/55, 15%). The COVID-19 and Influenza patients presented 1 (0−4) vs. 0 (0−4) secondary infections (p = 0.022), with comparable sites being affected (lungs: 35/61, 57% vs. 13/31, 42%; p = 0.16) and causative pathogens occurring (Gram-negative bacteria: 51/61, 84% vs. 23/31, 74%; p > 0.99). The COVID-19 patients had longer ICU lengths of stay (15 (−65) vs. 5 (1−89) days; p = 0.001), yet the two groups had comparable mortality rates (20/57, 35% vs. 23/55, 41%; p = 0.46). We report fewer co-infections but more secondary infections in the ICU COVID-19 patients compared to the Influenza patients. Most of the infectious complications were respiratory and of bacterial origin.
关于不同病毒感染的重症患者感染性并发症的数据较少。我们进行了一项回顾性单中心研究，纳入了截至2020年3月13日确诊为COVID-19或截至2015年1月1日确诊为甲型和/或乙型流感感染的所有入住重症监护病房（ICU）的患者，研究持续至2020年4月20日。记录了合并感染和继发感染（分别在入院后48小时内和48小时后发生）。纳入了57例COVID-19患者和55例流感患者。13/57（23%）的COVID-19患者与40/55（73%）的流感患者存在合并感染（p<0.001），其中大多数为呼吸道感染（9/13，69%对35/40，88%；p = 0.13）且为细菌源性（12/13，92%对29/40，73%；p = 0.25）。侵袭性曲霉感染仅在流感患者中观察到（8/55，15%）。COVID-19患者和流感患者继发感染分别为1例（0 - 4例）和0例（0 - 4例）（p = 0.022），受影响的部位相当（肺部：35/61，57%对13/31，42%；p = 0.16），致病病原体相同（革兰氏阴性菌：51/61，84%对23/31，74%；p>0.99）。COVID-19患者的ICU住院时间更长（15（-65）天对5（1 - 89）天；p = 0.001），但两组的死亡率相当（20/57，35%对23/55，41%；p = 0.46）。我们报告称，与流感患者相比，ICU中COVID-19患者的合并感染较少，但继发感染较多。大多数感染性并发症为呼吸道感染且为细菌源性。
