Wang Yanhuan, Zhao Xinping, Li Yurong, Wang Na, Jiang Feng, Lambert Helen, Yan Fei, Fu Chaowei, Jiang Qingwu
Key Laboratory of Public Health Safety, NHC Key Laboratory of Health Technology Assessment, School of Public Health, Fudan University, Shanghai 200032, China.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK.
Antibiotics (Basel). 2022 Jun 18;11(6):823. doi: 10.3390/antibiotics11060823.
Inappropriate antibiotic use may lead to antibiotic resistance, which has become a serious global crisis. Addressing suboptimal antibiotic use in the general population can play a significant role in the fight against antimicrobial resistance. This study aims to describe antibiotic use and sources of acquisition, and to identify factors influencing antibiotic access among rural community residents in Eastern China. A cross-sectional survey was conducted from July to August 2020, and 1494 participants from two villages in Eastern China were enrolled. Information was obtained using face-to-face interviews with a structured electronic questionnaire. Chi-squared and multinominal logistic regression analysis were used to explore possible determinants. In total, 1379 participants were eligible for the analysis. In the past 12 months, nearly half the respondents had taken any antibiotic (48.4%), and this proportion varied across marital status and age group. Two thirds of them (59.9%) obtained antibiotics from medical facilities with a prescription when they last took antibiotics, while 17.7% and 22.4% chose retail pharmacies and other sources, respectively. Multinominal analysis found that a higher proportion obtained antibiotics outside medical facilities among those aged 15 to 44 years, unmarried, non-white collar workers, with more years of education, lower annual household income per capita and lower levels of antibiotic knowledge. The antibiotic use behavior of rural community residents in Eastern China remains suboptimal. Antibiotic use and access behaviors need to be further addressed. Effective antibiotic stewardship in non-medical facility sources and training programs targeted for rural Chinese is warranted in future.
不恰当使用抗生素可能导致抗生素耐药性，这已成为一个严重的全球危机。解决普通人群中抗生素使用不规范的问题，在对抗抗菌药物耐药性方面可发挥重要作用。本研究旨在描述抗生素的使用情况和获取来源，并确定影响中国东部农村社区居民获取抗生素的因素。于2020年7月至8月进行了一项横断面调查，纳入了来自中国东部两个村庄的1494名参与者。通过面对面访谈使用结构化电子问卷获取信息。采用卡方检验和多项逻辑回归分析来探索可能的决定因素。共有1379名参与者符合分析条件。在过去12个月中，近一半的受访者使用过任何抗生素（48.4%），这一比例在婚姻状况和年龄组中有所不同。其中三分之二（59.9%）的人在最后一次使用抗生素时是从有处方的医疗机构获得的，而分别有17.7%和22.4%的人选择了零售药店和其他来源。多项分析发现，在15至44岁、未婚、非白领、受教育年限更多、人均家庭年收入较低且抗生素知识水平较低的人群中，有更高比例的人在医疗机构之外获取抗生素。中国东部农村社区居民的抗生素使用行为仍不理想。抗生素的使用和获取行为需要进一步加以解决。未来有必要在非医疗机构来源开展有效的抗生素管理工作，并针对中国农村地区开展培训项目。
