Coffino Philip, Cheng Yifan
Laboratory of Cellular Biophysics, Department of Molecular and Cell Biology, Rockefeller University, New York, NY 10065, USA.
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
Biomolecules. 2022 May 30;12(6):764. doi: 10.3390/biom12060764.
Allostery-regulation at distant sites is a key concept in biology. The proteasome exhibits multiple forms of allosteric regulation. This regulatory communication can span a distance exceeding 100 Ångstroms and can modulate interactions between the two major proteasome modules: its core particle and regulatory complexes. Allostery can further influence the assembly of the core particle with regulatory particles. In this focused review, known and postulated interactions between these proteasome modules are described. Allostery may explain how cells build and maintain diverse populations of proteasome assemblies and can provide opportunities for therapeutic interventions.
远处位点的变构调节是生物学中的一个关键概念。蛋白酶体表现出多种形式的变构调节。这种调节通讯的距离可超过100埃，并且可以调节蛋白酶体两个主要模块之间的相互作用：其核心颗粒和调节复合物。变构还可以进一步影响核心颗粒与调节颗粒的组装。在这篇重点综述中，描述了这些蛋白酶体模块之间已知的和推测的相互作用。变构可能解释细胞如何构建和维持蛋白酶体组装的多样化群体，并可为治疗干预提供机会。
