Wang Juan, Eming Sabine A, Ding Xiaolei
Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China.
Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China.
Biology (Basel). 2022 Jun 19;11(6):931. doi: 10.3390/biology11060931.
The skin epidermis, with its capacity for lifelong self-renewal and rapid repairing response upon injury, must maintain an active status in metabolism. Mechanistic target of rapamycin (mTOR) signaling is a central controller of cellular growth and metabolism that coordinates diverse physiological and pathological processes in a variety of tissues and organs. Recent evidence with genetic mouse models highlights an essential role of the mTOR signaling network in epidermal morphogenesis and barrier formation. In this review, we focus on the recent advances in understanding how mTOR signaling networks, including upstream inputs, kinases and downstream effectors, regulate epidermal morphogenesis and skin barrier formation. Understanding the details of the metabolic signaling will be critical for the development of novel pharmacological approaches to promote skin barrier regeneration and to treat epidermal barrier defect-associated diseases.
皮肤表皮具有终身自我更新的能力以及受伤后快速修复反应的能力，必须在新陈代谢中保持活跃状态。雷帕霉素的机制性靶点（mTOR）信号传导是细胞生长和新陈代谢的核心控制器，可协调各种组织和器官中的多种生理和病理过程。最近利用基因小鼠模型获得的证据突显了mTOR信号网络在表皮形态发生和屏障形成中的重要作用。在本综述中，我们重点关注在了解mTOR信号网络（包括上游输入、激酶和下游效应器）如何调节表皮形态发生和皮肤屏障形成方面的最新进展。了解代谢信号的细节对于开发促进皮肤屏障再生和治疗与表皮屏障缺陷相关疾病的新型药理学方法至关重要。
