Zhu Pei, Zhang Ying, Zhang Dianwei, Han Luxuan, Liu Huilin, Sun Baoguo
School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Foods. 2022 Jun 20;11(12):1813. doi: 10.3390/foods11121813.
As a special polyphenolic compound in oats, the physiological function of oat avenanthramides (AVAs) drives a variety of biological activities, and plays an important role in the prevention and treatment of common chronic diseases. In this study, the optimum extraction conditions and structural identification of AVAs from oats was studied. The inhibitory effect of AVAs from oats on advanced glycation end-products (AGEs) in a glucose-casein simulation system was evaluated, and this revealed dose-dependent inhibitory effects. The trapping capacity of AVAs to the α-dicarbonyl compounds of AGE intermediate products was determined by HPLC-MS/MS, and the results indicate that AVA 2c, AVA 2p, and AVA 2f exhibited the ability to capture -dicarbonyl compounds. More importantly, AVA 2f was found to be more efficient than AVA 2p at inhibiting superoxide anion radical (O), hydroxyl radical (OH), and singlet oxygen (O) radical generation, which may be the main reason that AVA 2f was more efficient than AVA 2p in AGE inhibition. Thus, this research presents a promising application of AVAs from oats in inhibiting the food-borne AGEs formed in food processing.
作为燕麦中的一种特殊多酚类化合物，燕麦 avenanthramides（AVAs）的生理功能驱动了多种生物活性，并在常见慢性病的防治中发挥重要作用。本研究对燕麦中 AVAs 的最佳提取条件和结构鉴定进行了研究。评估了燕麦中 AVAs 在葡萄糖 - 酪蛋白模拟体系中对晚期糖基化终产物（AGEs）的抑制作用，结果显示出剂量依赖性抑制效应。通过 HPLC-MS/MS 测定了 AVAs 对 AGE 中间产物α-二羰基化合物的捕获能力，结果表明 AVA 2c、AVA 2p 和 AVA 2f 具有捕获α-二羰基化合物的能力。更重要的是，发现 AVA 2f 在抑制超氧阴离子自由基（O）、羟基自由基（OH）和单线态氧（O）自由基生成方面比 AVA 2p 更有效，这可能是 AVA 2f 在抑制 AGEs 方面比 AVA 2p 更有效的主要原因。因此，本研究为燕麦中的 AVAs 在抑制食品加工过程中形成的食源性 AGEs 方面提供了有前景的应用。
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