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急性摄入燕麦饼干后人体对燕麦蒽酰胺的吸收与消除。

Absorption and Elimination of Oat Avenanthramides in Humans after Acute Consumption of Oat Cookies.

机构信息

Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA.

Department of Food Science and Nutrition, College of Food, Agriculture and Animal Science, University of Minnesota, St. Paul, MN 55108, USA.

出版信息

Oxid Med Cell Longev. 2017;2017:2056705. doi: 10.1155/2017/2056705. Epub 2017 Dec 21.

DOI:10.1155/2017/2056705
PMID:29430278
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5752969/
Abstract

BACKGROUND

Avenanthramides (AVA) are a group of diphenolic acids found only in oats that have anti-inflammatory and antioxidant effects. Absorption of AVAs in humans after oral consumption of natural oat flour is unknown.

OBJECTIVE

To examine the appearance of AVAs in plasma after oral ingestion of oat cookies and estimate key pharmacokinetic parameters.

METHODS

Male and female nonobese participants ( = 16) consumed three cookies made with oat flour containing high (229.6 mg/kg, H-AVA) or low (32.7 mg/kg, L-AVA) amounts of AVAs, including AVA-A, AVA-B, and AVA-C. Blood samples were collected at 0, 0.5, 1, 2, 3, 5, and 10 h after ingestion. Plasma total (conjugated and free) AVA concentrations were quantified using UPLC-MS, and pharmacokinetic parameters for each AVA were estimated.

RESULTS

AVAs reached peak concentrations in plasma between 2 and 3 h for the H-AVA group and between 1 and 2 h for the L-AVA group. Maximal plasma concentrations for AVAs were higher in the H-AVA than in the L-AVA group. AVA-B demonstrated a longer half-life and slower elimination rate than AVA-A and AVA-C.

CONCLUSIONS

AVAs found naturally in oats are absorbed in the plasma after oral administration in humans. AVA-B has the slowest elimination rate and the longest half-life compared to AVA-A and AVA-C, while AVA-C demonstrated the lowest plasma concentrations. This study is registered with ClinicalTrials.gov identifier NCT02415374.

摘要

背景

燕麦素（AVAs）是一组仅在燕麦中发现的二酚酸，具有抗炎和抗氧化作用。人类口服天然燕麦粉后对 AVAs 的吸收情况尚不清楚。

目的

研究口服燕麦饼干后 AVAs 在血浆中的出现情况，并估算关键药代动力学参数。

方法

16 名非肥胖男性和女性参与者分别食用了含有高（229.6mg/kg，H-AVA）或低（32.7mg/kg，L-AVA）量 AVAs（包括 AVA-A、AVA-B 和 AVA-C）的燕麦粉制成的 3 块饼干。在摄入后 0、0.5、1、2、3、5 和 10h 采集血样。使用 UPLC-MS 定量检测血浆中总（结合型和游离型）AVAs 浓度，并估算每种 AVA 的药代动力学参数。

结果

H-AVA 组 AVAs 于摄入后 2-3h 达到血浆峰浓度，L-AVA 组于 1-2h 达到血浆峰浓度。H-AVA 组各 AVA 的最大血浆浓度均高于 L-AVA 组。与 AVA-A 和 AVA-C 相比，AVA-B 的半衰期更长，消除率更慢。

结论

人类口服燕麦中天然存在的 AVAs 可被吸收到血浆中。与 AVA-A 和 AVA-C 相比，AVA-B 的消除率最慢，半衰期最长，而 AVA-C 的血浆浓度最低。本研究在 ClinicalTrials.gov 注册，标识符为 NCT02415374。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/5752969/5149778dd14d/OMCL2017-2056705.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/5752969/e8e79fb8fe93/OMCL2017-2056705.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/5752969/5149778dd14d/OMCL2017-2056705.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/5752969/e8e79fb8fe93/OMCL2017-2056705.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/5752969/5149778dd14d/OMCL2017-2056705.002.jpg

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