Applied Sports, Technology, Exercise and Medicine Research Centre, Bay Campus, Swansea, Wales SA1 8EN, UK.
Children's Health and Exercise Research Centre, University of Exeter, Exeter EX1 2LU, UK.
Int J Environ Res Public Health. 2022 Jun 10;19(12):7133. doi: 10.3390/ijerph19127133.
The aim of this study was to compare the use of generic and cystic fibrosis (CF)-specific cut-points to assess movement behaviours in children and adolescents with CF. Physical activity (PA) was assessed for seven consecutive days using a non-dominant wrist-worn ActiGraph GT9X in 71 children and adolescents (36 girls; 13.5 ± 2.9 years) with mild CF. CF-specific and generic Euclidean norm minus one (ENMO) cut-points were used to determine sedentary time (SED), sleep, light physical activity (LPA), moderate physical activity and vigorous physical activity. The effect of using a CF-specific or generic cut-point on the relationship between PA intensities and lung function was determined. Movement behaviours differed significantly according to the cut-point used, with the CF-specific cut-points resulting in less time asleep (−31.4 min; p < 0.01) and in LPA (−195.1 min; p < 0.001), and more SED and moderate-to-vigorous PA (159.3 and 67.1 min, respectively; both p < 0.0001) than the generic thresholds. Lung function was significantly associated with LPA according to the CF-specific cut-points (r = 0.52; p = 0.04). Thresholds developed for healthy populations misclassified PA levels, sleep and SED in children and adolescents with CF. This discrepancy affected the relationship between lung function and PA, which was only apparent when using the CF-specific cut-points. Promoting LPA seems a promising strategy to enhance lung function in children and adolescents with CF.
本研究旨在比较使用通用和囊性纤维化 (CF) 特定切点来评估 CF 患儿和青少年的运动行为。使用非优势手腕佩戴的 ActiGraph GT9X 在 71 名患有轻度 CF 的儿童和青少年（36 名女孩；13.5 ± 2.9 岁）中连续 7 天评估身体活动 (PA)。使用 CF 特定和通用欧几里得范数减一 (ENMO) 切点来确定久坐时间 (SED)、睡眠、轻度体力活动 (LPA)、中度体力活动和剧烈体力活动。确定使用 CF 特定或通用切点对 PA 强度与肺功能之间关系的影响。使用不同切点的运动行为存在显著差异，CF 特定切点导致睡眠时间减少（-31.4 分钟；p < 0.01）和 LPA 减少（-195.1 分钟；p < 0.001），SED 和中到高强度 PA 增加（分别为 159.3 和 67.1 分钟；p < 0.0001），而非通用阈值。根据 CF 特定切点，肺功能与 LPA 显著相关（r = 0.52；p = 0.04）。为健康人群制定的阈值错误分类了 CF 患儿和青少年的 PA 水平、睡眠和 SED。这种差异影响了肺功能与 PA 之间的关系，只有使用 CF 特定切点时才会出现这种关系。促进 LPA 似乎是增强 CF 患儿和青少年肺功能的一种有前途的策略。
