National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Int J Environ Res Public Health. 2022 Jun 16;19(12):7422. doi: 10.3390/ijerph19127422.
The aim of this paper was to assess the association between desalinated seawater and cardiovascular diseases (CVDs). We conducted a nested case-control prospective study on a cohort of 7806 subjects who live on an island of China that lacks fresh water. From this cohort, we identified 140 paired CVD cases and matched controls by sex and age during the same period. Questionnaires were used in order to investigate basic sociodemographic information and risk factors for CVDs, and urine samples were collected to measure calcium and magnesium levels. Using these data we developed and tested both univariate and multivariate logistic regression models. We observed no significant differences in risk of CVDs between groups with desalinated seawater and fresh water intake. From multivariate logistic regression, we found that obesity (OR = 5.38, 95% CI: 1.05-27.45), physical activity (OR = 0.35, 95% CI: 0.16-0.75), hypertension (OR = 3.61, 95% CI: 1.58-8.25), alcohol consumption (OR = 2.57, 95% CI: 1.02-6.47), and irritability (OR = 4.30, 95% CI: 1.93-9.60) were associated with an increased risk of CVD. In this population, we found no association between desalinated seawater intake and CVDs; the incidence of CVDs was primarily related to lifestyle.
本研究旨在评估脱盐水与心血管疾病（CVD）之间的关联。我们对居住在中国一个缺乏淡水的岛屿上的 7806 名受试者进行了一项嵌套病例对照前瞻性研究。从该队列中，我们按照性别和同期年龄确定了 140 对 CVD 病例和匹配对照。我们采用问卷调查的方式来调查 CVD 的基本社会人口学信息和危险因素，并收集尿液样本以测量钙和镁的水平。利用这些数据，我们开发并测试了单变量和多变量逻辑回归模型。我们发现，饮用脱盐水和淡水组的 CVD 风险无显著差异。多变量逻辑回归显示，肥胖（OR=5.38，95%CI：1.05-27.45）、体力活动（OR=0.35，95%CI：0.16-0.75）、高血压（OR=3.61，95%CI：1.58-8.25）、饮酒（OR=2.57，95%CI：1.02-6.47）和易怒（OR=4.30，95%CI：1.93-9.60）与 CVD 风险增加相关。在本研究人群中，我们未发现脱盐水摄入与 CVD 之间存在关联；CVD 的发病主要与生活方式有关。
