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全面综合的单细胞全转录组分析揭示了口腔鳞状细胞癌中 p-EMT 肿瘤细胞-CAFs 的通讯。

Comprehensive Integrated Single-Cell Whole Transcriptome Analysis Revealed the p-EMT Tumor Cells-CAFs Communication in Oral Squamous Cell Carcinoma.

机构信息

Laboratory of Oral-Maxillofacial Biology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 749000, Vietnam.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.

出版信息

Int J Mol Sci. 2022 Jun 9;23(12):6470. doi: 10.3390/ijms23126470.

DOI:10.3390/ijms23126470
PMID:35742914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9223794/
Abstract

Cancer-associated fibroblasts (CAFs) and partial epithelial-mesenchymal transition (p-EMT) tumor cells are closed together and contribute to the tumor progression of oral squamous cell carcinoma (OSCC). In the present study, we deeply analyzed and integrated OSCC single-cell RNA sequencing datasets to define OSCC CAFs and p-EMT subpopulations. We highlighted the cell-cell interaction network of CAFs and p-EMT tumor cells and suggested biomarkers for the diagnosis and prognosis of OSCC during the metastasis condition. The analysis discovered four subtypes of CAFs: one p-EMT tumor cell population, and cycling tumor cells as well as TNFSF12-TNFRSF25/TNFRSF12A interactions between CAFs and p-EMT tumor cells during tumor metastasis. This suggests the prediction of therapeutically targetable checkpoint receptor-ligand interactions between CAFs and p-EMT tumor cells in OSCC regarding the metastasis status.

摘要

癌症相关成纤维细胞 (CAFs) 和部分上皮-间充质转化 (p-EMT) 肿瘤细胞紧密相连，共同促进口腔鳞状细胞癌 (OSCC) 的肿瘤进展。在本研究中，我们深入分析和整合了 OSCC 单细胞 RNA 测序数据集，以定义 OSCC CAFs 和 p-EMT 亚群。我们强调了 CAFs 和 p-EMT 肿瘤细胞的细胞-细胞相互作用网络，并提出了在转移条件下用于 OSCC 诊断和预后的生物标志物。分析发现了四种 CAFs 亚型：一个 p-EMT 肿瘤细胞群体，以及循环肿瘤细胞和 TNFSF12-TNFRSF25/TNFRSF12A 之间的相互作用 CAFs 和 p-EMT 肿瘤细胞在肿瘤转移过程中。这表明可以预测 OSCC 中 CAFs 和 p-EMT 肿瘤细胞之间在转移状态下具有治疗潜力的检查点受体-配体相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/506b/9223794/e2ce0e8ca10c/ijms-23-06470-g005.jpg
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