Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, Università degli Studi di Milano Bicocca, 20900 Monza, Italy.
European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, 20900 Monza, Italy.
Int J Mol Sci. 2022 Jun 14;23(12):6649. doi: 10.3390/ijms23126649.
Chronic inflammation is the hallmark of fibrotic disorders and is characterized by the activation of immune cells in the damaged tissues. Macrophages have emerged as central players in the fibrotic process since they initiate, sustain and amplify the inflammatory reaction. As regards the liver, distinct populations of phagocytic cells, like Kupffer cells and monocyte-derived macrophages, are indisputably key cells implicated in the pathogenesis of several chronic liver diseases. In this review, we summarize the current knowledge on the origin, role and functions of macrophages in fibrotic conditions, with a specific focus on liver fibrosis; then, we discuss some innovative therapeutic strategies targeting macrophages in fibrotic liver diseases.
慢性炎症是纤维化疾病的标志，其特征是受损组织中免疫细胞的激活。巨噬细胞作为纤维化过程中的核心参与者而出现，因为它们启动、维持和放大炎症反应。就肝脏而言，吞噬细胞的不同群体，如库普弗细胞和单核细胞衍生的巨噬细胞，无疑是几种慢性肝病发病机制中涉及的关键细胞。在这篇综述中，我们总结了目前关于巨噬细胞在纤维化状态中的起源、作用和功能的知识，特别关注肝纤维化；然后，我们讨论了一些针对纤维化性肝病中巨噬细胞的创新治疗策略。
Zotero 插件
