Choi Hyo Geun, Kang Ho Suk, Lim Hyun, Kim Joo-Hee, Kim Ji Hee, Cho Seong-Jin, Nam Eun Sook, Min Kyueng-Whan, Park Ha Young, Kim Nan Young, Kwon Mi Jung
Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea.
Department of Internal Medicine, Division of Gastroenterology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea.
J Pers Med. 2022 Jun 13;12(6):965. doi: 10.3390/jpm12060965.
The potential link between rheumatoid arthritis (RA) and cancer incidence needs to be validated due to inconsistent results between Asian and Western countries. We explored the long-term association of RA with the overall and organ-specific cancer incidence using nationwide population data. This longitudinal follow-up study (2002-2015) included 3070 patients with RA and 12,280 controls (1:4 propensity score-matched for sex, age, residence, and income) from the Korean National Health Insurance Service-Health Screening Cohort database. A Cox proportional hazard model estimated the hazard ratio for malignancy following adjusting for covariates. Despite the similar overall cancer incidence between RA and control groups, differences in the incidence of organ-specific cancers were noted: the RA group had a 1.63-fold greater likelihood for lung cancer (95% confidence interval 1.11-2.40). In the sex-stratified subgroup analyses, the male RA patients exhibited higher odds of lung and thyroid cancer but a lower probability for colorectal cancer; no such associations were detected in either female patients with RA or age subgroups. In summary, the higher likelihood for lung cancer in Korean RA patients, especially thyroid and lung cancer in male RA patients, seems to be characteristic, which needs to be carefully monitored.
由于亚洲和西方国家之间的结果不一致，类风湿性关节炎（RA）与癌症发病率之间的潜在联系需要得到验证。我们使用全国性人口数据探讨了RA与总体癌症及器官特异性癌症发病率之间的长期关联。这项纵向随访研究（2002年至2015年）纳入了来自韩国国民健康保险服务健康筛查队列数据库的3070例RA患者和12280例对照（按性别、年龄、居住地和收入进行1:4倾向评分匹配）。Cox比例风险模型在调整协变量后估计了恶性肿瘤的风险比。尽管RA组和对照组的总体癌症发病率相似，但注意到器官特异性癌症发病率存在差异：RA组患肺癌的可能性高1.63倍（95%置信区间1.11 - 2.40）。在按性别分层的亚组分析中，男性RA患者患肺癌和甲状腺癌的几率较高，但患结直肠癌的概率较低；在女性RA患者或年龄亚组中均未检测到此类关联。总之，韩国RA患者患肺癌的可能性较高，尤其是男性RA患者患甲状腺癌和肺癌，这似乎是其特征，需要仔细监测。
