Graziani Cristina, Laterza Lucrezia, Talocco Claudia, Pizzoferrato Marco, Di Simone Nicoletta, D'Ippolito Silvia, Ricci Caterina, Gervasoni Jacopo, Persichilli Silvia, Del Chierico Federica, Marzano Valeria, Mortera Stefano Levi, Primiano Aniello, Poscia Andrea, Ponziani Francesca Romana, Putignani Lorenza, Urbani Andrea, Petito Valentina, Di Vincenzo Federica, Masi Letizia, Lopetuso Loris Riccardo, Cammarota Giovanni, Romualdi Daniela, Lanzone Antonio, Gasbarrini Antonio, Scaldaferri Franco
CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
J Pers Med. 2022 Jun 20;12(6):1005. doi: 10.3390/jpm12061005.
Recurrent cystitis (RC) is a common disease, especially in females. Anatomical, behavioral and genetic predisposing factors are associated with the ascending retrograde route, which often causes bladder infections. RC seems to be mainly caused by agents derived from the intestinal microbiota, and most frequently by . Intestinal contiguity contributes to the etiopathogenesis of RC and an alteration in intestinal permeability could have a major role in RC. The aim of this pilot study is to assess gut microbiome dysbiosis and intestinal permeability in female patients with RC. Patients with RC ( = 16) were enrolled and compared with healthy female subjects ( = 15) and patients with chronic gastrointestinal (GI) disorders ( = 238). We calculated the Acute Cystitis Symptom Score/Urinary Tract Infection Symptom Assessment (ACSS/UTISA) and Gastrointestinal Symptom Rating Scale (GSRS) scores and evaluated intestinal permeability and the fecal microbiome in the first two cohorts. Patients with RC showed an increased prevalence of gastrointestinal symptoms compared with healthy controls. Of the patients with RC, 88% showed an increased intestinal permeability with reduced biodiversity of gut microbiota compared to healthy controls, and 68% of the RC patients had a final diagnosis of gastrointestinal disease. Similarly, GI patients reported a higher incidence of urinary symptoms with a diagnosis of RC in 20%. Gut barrier impairment seems to play a major role in the pathogenesis of RC. Further studies are necessary to elucidate the role of microbiota and intestinal permeability in urinary tract infections.
复发性膀胱炎（RC）是一种常见疾病，尤其在女性中更为常见。解剖学、行为学和遗传易感性因素与逆行上升途径相关，这一途径常导致膀胱感染。RC似乎主要由源自肠道微生物群的病原体引起，最常见的是由 引起。肠道连续性促成了RC的发病机制，肠道通透性的改变可能在RC中起主要作用。这项初步研究的目的是评估女性RC患者的肠道微生物群失调和肠道通透性。纳入了16例RC患者，并与15例健康女性受试者以及238例慢性胃肠道（GI）疾病患者进行比较。我们计算了急性膀胱炎症状评分/尿路感染症状评估（ACSS/UTISA）和胃肠道症状评分量表（GSRS）得分，并在前两个队列中评估了肠道通透性和粪便微生物群。与健康对照组相比，RC患者出现胃肠道症状的患病率更高。在RC患者中，88%的患者肠道通透性增加，肠道微生物群的生物多样性降低，与健康对照组相比，68%的RC患者最终被诊断为胃肠道疾病。同样，GI疾病患者报告有更高的泌尿系统症状发生率，其中20%被诊断为RC。肠道屏障受损似乎在RC的发病机制中起主要作用。有必要进行进一步研究以阐明微生物群和肠道通透性在尿路感染中的作用。
