Adam Cristina Andreea, Anghel Razvan, Marcu Dragos Traian Marius, Mitu Ovidiu, Roca Mihai, Mitu Florin
Clinical Rehabilitation Hospital, Cardiovascular Rehabilitation Clinic, Pantelimon Halipa Street nr. 14, 700661 Iaşi, Romania.
Department of Internal Medicine, University of Medicine and Pharmacy, Grigore T. Popa, University Street nr. 16, 700115 Iaşi, Romania.
Life (Basel). 2022 May 27;12(6):803. doi: 10.3390/life12060803.
Vascular aging, early vascular aging or supernormal vascular aging are concepts used for estimating the cardiovascular risk at a certain age. From the famous line of Thomas Sydenham that "a man is as old as his arteries" to the present day, clinical studies in the field of molecular biology of the vasculature have demonstrated the active role of vascular endothelium in the onset of cardiovascular diseases. Arterial stiffness is an important cardiovascular risk factor associated with the occurrence of cardiovascular events and a high risk of morbidity and mortality, especially in the presence of diabetes. Sodium-glucose cotransporter 2 inhibitors decrease arterial stiffness and vascular resistance by decreasing endothelial cell activation, stimulating direct vasorelaxation and ameliorating endothelial dysfunction or expression of pro-atherogenic cells and molecules.
血管衰老、早期血管衰老或超常血管衰老都是用于评估特定年龄心血管风险的概念。从托马斯·西德纳姆那句著名的“人如其动脉般衰老”到如今，血管系统分子生物学领域的临床研究已证实血管内皮在心血管疾病发病过程中的积极作用。动脉僵硬度是与心血管事件发生以及高发病和死亡风险相关的重要心血管危险因素，尤其是在糖尿病患者中。钠-葡萄糖协同转运蛋白2抑制剂通过减少内皮细胞活化、刺激直接血管舒张以及改善内皮功能障碍或促动脉粥样硬化细胞和分子的表达来降低动脉僵硬度和血管阻力。
