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使用耳部电刺激和磁刺激原型设备评估主观性耳鸣治疗效果——初步研究

Assessment of Subjective Tinnitus Treatment Results Using a Prototype Device for Electrical and Magnetic Stimulation of the Ear-Preliminary Study.

作者信息

Olszewski Jurek, Bielińska Marzena, Kowalski Andrzej Julian

机构信息

Department of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics, II Chair of Otolaryngology, Medical University of Lodz, 90-549 Lodz, Poland.

出版信息

Life (Basel). 2022 Jun 19;12(6):918. doi: 10.3390/life12060918.

DOI:10.3390/life12060918
PMID:35743949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9225432/
Abstract

: The aim of the study was to evaluate the effectiveness of subjective tinnitus treatment in patients with cochlear sensorineural hearing loss with magnetic ear stimulation using a prototype device. Since the 1970s, studies have been conducted on the use of electrical stimulation of the ear in the treatment of tinnitus. The available literature contains various hypotheses about the influence of electrical stimulation of the ear on tinnitus. : Preclinical studies were performed for 100 patients, 40 women and 60 men (124 ears in total), aged 38-72 years, treated for tinnitus. A subjective assessment of the loudness of tinnitus was performed, and the frequency and intensity as well as hearing threshold were determined using a prototype device for electro-magnetic stimulation of the ear. The treatment cycle consisted of 10 five-minute stimulations performed daily 5 times a week. Before treatment, persistent tinnitus was found in 100 ears (80.6%) and periodic tinnitus in 24 ears (19.4%). Immediately after treatment, persistent tinnitus was present only in 50 ears (40.3%) and periodic tinnitus in 40 ears (32.3%). Complete resolution of tinnitus was noted in 34 ears (27.4%). On the other hand, the examination performed 3 months after the treatment showed persistent tinnitus in 40 ears (32.3%) and periodic tinnitus in 50 ears (40.3%), and complete resolution of tinnitus was recorded in 34 ears (27.4%). Based on the VAS analog scale, there was an improvement in tinnitus in 98 ears (79.0%) immediately after treatment and no improvement in 26 ears (20.0%). The mean VAS scale before treatment was 4.9 points, after treatment it was 2.1 points and 3 months after treatment it was 1.9 points. The preliminary research results show the high effectiveness of magnetic stimulation in the treatment of tinnitus with the use of a prototype device for electromagnetic stimulation of the ear. There was no negative effect of the stimulation on hearing or tinnitus.

摘要

本研究的目的是使用一种原型设备,通过磁耳刺激来评估主观耳鸣治疗对耳蜗性感音神经性听力损失患者的有效性。自20世纪70年代以来,人们一直在进行关于使用耳部电刺激治疗耳鸣的研究。现有文献包含了关于耳部电刺激对耳鸣影响的各种假说。对100例耳鸣患者进行了临床前研究,其中女性40例,男性60例(共124只耳),年龄在38 - 72岁之间。对耳鸣响度进行了主观评估,并使用耳部电磁刺激原型设备测定了频率、强度以及听力阈值。治疗周期包括每周5次,每次10次五分钟的刺激,每天进行。治疗前,100只耳(80.6%)存在持续性耳鸣,24只耳(19.4%)存在周期性耳鸣。治疗后即刻,仅50只耳(40.3%)存在持续性耳鸣,40只耳(32.3%)存在周期性耳鸣。34只耳(27.4%)耳鸣完全消失。另一方面,治疗后3个月的检查显示,40只耳(32.3%)存在持续性耳鸣,50只耳(40.3%)存在周期性耳鸣,34只耳(27.4%)耳鸣完全消失。基于视觉模拟评分法(VAS),治疗后即刻98只耳(79.0%)耳鸣有改善,26只耳(20.0%)无改善。治疗前VAS平均评分为4.9分,治疗后为2.1分,治疗后3个月为1.9分。初步研究结果表明,使用耳部电磁刺激原型设备进行磁刺激治疗耳鸣具有很高的有效性。刺激对听力或耳鸣没有负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4700/9225432/2aae0cd9d8f1/life-12-00918-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4700/9225432/559698d9ec3c/life-12-00918-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4700/9225432/76455bf35dde/life-12-00918-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4700/9225432/a7a92401d49b/life-12-00918-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4700/9225432/2aae0cd9d8f1/life-12-00918-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4700/9225432/559698d9ec3c/life-12-00918-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4700/9225432/76455bf35dde/life-12-00918-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4700/9225432/a7a92401d49b/life-12-00918-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4700/9225432/2aae0cd9d8f1/life-12-00918-g004.jpg

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One Size Does Not Fit All: Developing Common Standards for Outcomes in Early-Phase Clinical Trials of Sound-, Psychology-, and Pharmacology-Based Interventions for Chronic Subjective Tinnitus in Adults.一刀切并不适合所有人:为成人慢性主观性耳鸣的基于声音、心理学和药理学的早期临床试验制定共同结局标准。
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