Khoo Mohammad Shukri, Ali Adli
Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia Children's Specialist Hospital, The National University of Malaysia, Kuala Lumpur 56000, Malaysia.
Research Centre, Universiti Kebangsaan Malaysia Children's Specialist Hospital, The National University of Malaysia, Kuala Lumpur 56000, Malaysia.
Trop Med Infect Dis. 2023 Jul 29;8(8):388. doi: 10.3390/tropicalmed8080388.
The definitive role of viral infections, such as rotavirus, in causing Kawasaki disease (KD) remains uncertain. However, the intriguing observation of concomitant rotavirus infection and KD suggests a potential association. This study aimed to investigate this relationship. We reported a case of concomitant KD and rotavirus infection complicated by hyponatraemia and anasarca. For the systematic review, we used three large databases, namely PubMed, Ovid, and Scopus, to search articles with the terms "Kawasaki" and "rotavirus". We also used Google Scholar as our secondary source. We included articles that fulfilled the following criteria: (i) articles reporting on children aged 18 and below; (ii) articles reporting on patients infected with rotavirus prior to or concomitant with KD; and (iii) articles written in English only. Three articles were included and analysed in combination with our reported patient. All patients exhibited gastrointestinal symptoms, including diarrhoea and vomiting, in addition to non-resolving fevers, which eventually manifested more signs and symptoms to support the diagnosis of KD. Stool samples from all patients revealed positive rotavirus antigens. Two patients (n = 2) were noted to have hyponatraemia and hypoalbuminaemia. Three (n = 3) manifested coronary artery abnormalities (CAA). Even though the relationship is not fully understood yet, it is known that the combination of these two pathologies can cause catastrophic immune responses and complications.
轮状病毒等病毒感染在川崎病（KD）发病中的决定性作用仍不明确。然而，轮状病毒感染与KD同时出现这一有趣的现象提示了二者之间可能存在关联。本研究旨在探究这种关系。我们报告了1例同时患有KD和轮状病毒感染并伴有低钠血症和全身水肿的病例。为进行系统评价，我们使用了三个大型数据库，即PubMed、Ovid和Scopus，以“川崎病”和“轮状病毒”为关键词搜索文章。我们还将谷歌学术作为辅助来源。我们纳入了符合以下标准的文章：（i）报道18岁及以下儿童的文章；（ii）报道在KD之前或同时感染轮状病毒的患者的文章；（iii）仅用英文撰写的文章。共纳入3篇文章，并与我们报告的病例进行综合分析。所有患者除持续发热外，均出现胃肠道症状，包括腹泻和呕吐，最终表现出更多支持KD诊断的体征和症状。所有患者的粪便样本轮状病毒抗原均呈阳性。2例患者（n = 2）出现低钠血症和低白蛋白血症。3例（n = 3）出现冠状动脉异常（CAA）。尽管二者之间的关系尚未完全明确，但已知这两种病理情况同时出现可引发灾难性的免疫反应和并发症。
