Grenda Anna, Grenda Tomasz, Domaradzki Piotr, Kwiatek Krzysztof
Department of Pneumonology, Oncology and Allergology, Medical University in Lublin, Jaczewskiego 8, 20-950 Lublin, Poland.
Department of Hygiene of Animal Feeding Stuffs, National Veterinary Research Institute, Partyzantow 57, 24-100 Pulawy, Poland.
Pathogens. 2022 Jun 15;11(6):687. doi: 10.3390/pathogens11060687.
spp. are Gram-positive, heterogeneous lactic acid bacteria inhabiting various environments. Several species of Enterococci are considered to be able to stimulate the immune system and play an important role in intestinal homeostasis. Some Enterococci can be used as probiotics. Some strains of are components of pharmaceutical products used to treat diarrhea, antibiotic-associated diarrhea, or irritable bowel syndrome (IBS). However, it has been proved that they are responsible for food contamination, and are sometimes undesirable from the point of view of food technology. Additionally, the virulence and multi-drug resistance of Enterococci potentially pose a risk of an epidemic, especially in hospital environments. Moreover, there are indications of their negative role in colon tumorigenesis; however, some nterococci are proved to support immunotherapy in cancer treatment. In general, it can be concluded that this group of microorganisms, despite its nature, has properties that can be used to support cancer treatment-both aggressive chemotherapy and cutting-edge therapy targeting immune checkpoints (IC).
肠球菌属是革兰氏阳性、异质性乳酸菌，存在于各种环境中。几种肠球菌被认为能够刺激免疫系统，并在肠道内环境稳定中发挥重要作用。一些肠球菌可用作益生菌。某些菌株是用于治疗腹泻、抗生素相关性腹泻或肠易激综合征（IBS）的药品成分。然而，已证实它们会导致食品污染，从食品技术角度来看有时是不受欢迎的。此外，肠球菌的毒力和多重耐药性可能引发流行风险，尤其是在医院环境中。而且，有迹象表明它们在结肠肿瘤发生中起负面作用；然而，一些肠球菌被证明在癌症治疗中支持免疫疗法。总体而言，可以得出结论，这组微生物尽管具有其特性，但具有可用于支持癌症治疗的特性——无论是积极的化疗还是针对免疫检查点（IC）的前沿疗法。
