Souêtre E, Candito M, Salvati E, Pringuey D, Chambon P, Darcourt G
Neuropsychobiology. 1986;16(1):1-8. doi: 10.1159/000118289.
The circadian rhythm of plasma norepinephrine (NE) was investigated in the depressed (major affective disorder, DSM III; n = 12), recovered (after 3 weeks of treatment using usual antidepressant drugs; n = 12) and normal (volunteers, age and sex matched; n = 10) states. Data analysis (based on the evaluation of circadian parameters, on the chronogram method and on the chronobiological analysis) revealed a clear NE circadian rhythm in normal subjects, a rhythm which was disturbed in depression, with amplitude reduction and abnormal phase position. These abnormalities tended to disappear during recovery since circadian parameters were similar to those of controls. These circadian abnormalities could be linked to the impairment of the peripheral and central catecholaminergic systems. They may also support the chronobiological hypothesis of affective disorders.
对处于抑郁状态（重度情感障碍，DSM-III；n = 12）、康复状态（使用常规抗抑郁药物治疗3周后；n = 12）和正常状态（年龄和性别匹配的志愿者；n = 10）的人群，研究了血浆去甲肾上腺素（NE）的昼夜节律。数据分析（基于昼夜节律参数评估、时序图法和时间生物学分析）显示，正常受试者存在明显的NE昼夜节律，而在抑郁症患者中该节律受到干扰，表现为振幅降低和相位位置异常。这些异常在康复过程中趋于消失，因为昼夜节律参数与对照组相似。这些昼夜节律异常可能与外周和中枢儿茶酚胺能系统的损害有关。它们也可能支持情感障碍的时间生物学假说。
