Souetre E, Salvati E, Pringuey D, Krebs B, Plasse Y, Darcourt G
Clinique de psychiatrie et de psychologie médicale, Hôpital Pasteur, Nice, France.
Chronobiol Int. 1986;3(3):197-205. doi: 10.3109/07420528609066367.
The 24-hr patterns of plasma thyrotropin have been observed in 12 endogenous depressed patients in both depressed and recovered states and in 13 normal subjects. A clear circadian rhythm was detected in controls with high values at night. In depression, the circadian rhythm was altered with amplitude reduction and blunted nocturnal secretion, abnormalities particularly relevant in bipolar patients. This flattened profile could be linked to the blunted response of TSH to TRH administration reported in depressed patients. Normal nyctohemeral patterns have been restored after recovery. These chronobiological abnormalities as well as their normalization under antidepressant drugs seem to be similar to those reported for various parameters (e.g. temperature, cortisol, etc) in depression which could support the chronobiological hypothesis for affective disorders.
在12名内源性抑郁症患者的抑郁状态和康复状态下以及13名正常受试者中观察了促甲状腺激素的24小时血浆模式。在对照组中检测到明显的昼夜节律，夜间值较高。在抑郁症中，昼夜节律发生改变，振幅降低，夜间分泌减弱，这些异常在双相情感障碍患者中尤为相关。这种平坦的曲线可能与抑郁症患者中促甲状腺激素对促甲状腺激素释放激素给药的反应减弱有关。康复后恢复了正常的昼夜模式。这些时间生物学异常及其在抗抑郁药物作用下的正常化似乎与抑郁症中各种参数（如体温、皮质醇等）报道的情况相似，这可能支持情感障碍的时间生物学假说。
