Souêtre E, Salvati E, Belugou J L, Pringuey D, Candito M, Krebs B, Ardisson J L, Darcourt G
Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France.
Psychiatry Res. 1989 Jun;28(3):263-78. doi: 10.1016/0165-1781(89)90207-2.
Circadian rhythms of body temperature, plasma cortisol, norepinephrine (NE), thyroid stimulating hormone (TSH), and melatonin were compared in 16 endogenously depressed, 15 recovered (after 3 weeks of anti-depressant treatment), and 16 normal subjects. The depressed patients showed clear circadian rhythm abnormalities, consisting mainly in amplitude reduction. This amplitude reduction was significantly correlated with the patients' Hamilton depression scores. Normal circadian profiles were restored after recovery when amplitude, in particular, was increased. Features of the circadian rhythms observed in remission may be associated with antidepressant drug effects, whereas those observed in depression resemble the circadian rhythms observed in normal subjects living under conditions of temporal isolation and those of blind subjects. Our findings suggest that depression may be related both to a weakening of the coupling processes between internal pacemakers and to an abnormal sensitivity to environmental information.
对16名内源性抑郁症患者、15名康复者（经过3周抗抑郁治疗后）以及16名正常受试者的体温、血浆皮质醇、去甲肾上腺素（NE）、促甲状腺激素（TSH）和褪黑素的昼夜节律进行了比较。抑郁症患者表现出明显的昼夜节律异常，主要表现为振幅降低。这种振幅降低与患者的汉密尔顿抑郁评分显著相关。康复后昼夜节律恢复正常，尤其是振幅增加。缓解期观察到的昼夜节律特征可能与抗抑郁药物的作用有关，而抑郁症患者观察到的昼夜节律类似于在时间隔离条件下生活的正常受试者以及盲人受试者的昼夜节律。我们的研究结果表明，抑郁症可能既与内部起搏器之间耦合过程的减弱有关，也与对环境信息的异常敏感性有关。
