Choi Yunjung, Lee Chang Hun, Kim Kyoung Min, Yoo Wan-Hee
Division of Rheumatology, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju City 54907, Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju City 54907, Korea.
Vaccines (Basel). 2022 Jun 9;10(6):923. doi: 10.3390/vaccines10060923.
IgA vasculitis is an immune complex-mediated small-vessel vasculitis that mainly occurs in children and is characterized by palpable purpura, arthralgia, abdominal pain, and glomerulonephritis. We report three cases of new-onset IgA vasculitis involving major organs in adult patients after they received either the ChAdOx1 viral vector (Oxford/AstraZeneca) vaccine or the messenger RNA-1273 (Moderna) vaccine. These cases suggest that COVID-19 vaccines have the potential to trigger IgA vasculitis and indicate that physicians need to monitor for this possible complication.
IgA血管炎是一种免疫复合物介导的小血管炎，主要发生于儿童，其特征为可触及的紫癜、关节痛、腹痛和肾小球肾炎。我们报告了3例成年患者在接种ChAdOx1病毒载体（牛津/阿斯利康）疫苗或信使核糖核酸-1273（莫德纳）疫苗后新发累及主要器官的IgA血管炎病例。这些病例提示，2019冠状病毒病（COVID-19）疫苗有可能引发IgA血管炎，并表明医生需要监测这种可能的并发症。
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