“卫星V”疫苗在奥密克戎毒株占主导期间对预防新冠病毒感染导致的住院治疗的有效性
Sputnik V Effectiveness against Hospitalization with COVID-19 during Omicron Dominance.
作者信息
Shkoda Andrey S, Gushchin Vladimir A, Ogarkova Darya A, Stavitskaya Svetlana V, Orlova Olga E, Kuznetsova Nadezhda A, Keruntu Elena N, Pochtovyi Andrei A, Pukhov Alexander V, Kleymenov Denis A, Krzhanovsky Vasyli G, Vasina Daria V, Shkuratova Nataliya V, Shidlovskaya Elena V, Gorbunov Alexey L, Kustova Daria D, Mazurina Evgeniya A, Kozlova Sofya R, Soboleva Alexandra V, Grigoriev Igor V, Pankratyeva Lyudmila L, Odintsova Alina S, Belyaeva Elizaveta D, Bessonova Arina A, Vasilchenko Lyudmila A, Lupu Igor P, Adgamov Ruslan R, Tkachuk Artem P, Tokarskaya Elizaveta A, Logunov Denis Y, Gintsburg Alexander L
机构信息
City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia.
Federal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
出版信息
Vaccines (Basel). 2022 Jun 13;10(6):938. doi: 10.3390/vaccines10060938.
Mass vaccination campaigns against COVID-19 affected more than 90% of the population in most developed countries. The new epidemiologic wave of COVID-19 has been ongoing since the end of 2021. It is caused by a virus variant B.1.1.529, also known as "Omicron" and its descendants. The effectiveness of major vaccines against Omicron is not known. The purpose of this study is to evaluate the efficacy of the Sputnik V vaccine. The main goal is to assess its protection against hospitalization in the period of Omicron dominance. We conducted our study based on a large clinical center in Moscow (Russia) where 1112 patients were included. We used the case-population method to perform the calculations. The data we obtained indicate that the Omicron variant causes at least 90% of infections in the studied cohort. The effectiveness of protection against hospitalization with COVID-19 in our study was 85.9% (95% CI 83.0-88.0%) for those who received more than one dose. It was 87.6% (95% CI 85.4-89.5%) and 97.0% (95% CI 95.9-97.8%) for those who received more than two or three doses. The effectiveness in cases of more severe forms was higher than for less severe ones. Thus, present study indicates the high protective efficacy of vaccination against hospitalization with COVID-19 in case of Omicron lineage.
针对新冠病毒的大规模疫苗接种运动影响了大多数发达国家超过90%的人口。自2021年底以来，新冠病毒新的流行浪潮一直在持续。它是由一种名为B.1.1.529的病毒变种引起的，该变种也被称为“奥密克戎”及其后代。主要疫苗对奥密克戎的有效性尚不清楚。本研究的目的是评估卫星V疫苗的疗效。主要目标是评估其在奥密克戎占主导期间对住院治疗的保护作用。我们在莫斯科（俄罗斯）的一个大型临床中心开展了研究，纳入了1112名患者。我们采用病例人群法进行计算。我们获得的数据表明，在研究队列中，奥密克戎变种导致了至少90%的感染。在我们的研究中，对于接种超过一剂疫苗的人，预防新冠病毒住院治疗的有效性为85.9%（95%置信区间83.0 - 88.0%）。对于接种超过两剂或三剂疫苗的人，有效性分别为87.6%（95%置信区间85.4 - 89.5%）和97.0%（95%置信区间95.9 - 97.8%）。在病情更严重的情况下，有效性高于病情较轻的情况。因此，本研究表明在奥密克戎毒株流行时，接种疫苗预防新冠病毒住院治疗具有很高的保护效力。
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