Sukhikh Gennady T, Priputnevich Tatiana V, Ogarkova Darya A, Pochtovyi Andrei A, Kustova Daria D, Zlobin Vladimir I, Logunov Denis Y, Gushchin Vladimir A, Gintsburg Alexander L
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health, 117997 Moscow, Russia.
Federal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Vaccines (Basel). 2022 Oct 26;10(11):1804. doi: 10.3390/vaccines10111804.
Medical personnel are a group of people that often encounter infectious agents, leading to greater risk of contracting infectious diseases. Specific prevention of diseases in this group is a priority. The epidemiological effectiveness of COVID-19 prevention in the group of medical workers due to the emergence of new variants of concern of the SARS-CoV-2 virus has not been studied in sufficient depth. We conducted a study of the effectiveness of vaccine use to protect medical workers at a large medical center for obstetrics and gynecology in Moscow. Sputnik V and Sputnik Light were the main vaccines used for the prevention of COVID-19. The vaccines are based on a variant of the S-protein of the SARS-CoV-2 virus, with adenovirus serotypes 5 and 26 as the vector for delivery. Vaccination of employees occurred during the period in which the Delta variant was spreading. The overall epidemiological effectiveness was 81.7% (73.1-87.6%) during the period in which the Delta variant was dominant. During the period from the beginning of vaccination (26 November 2020) until 8 February 2022, the overall effectiveness was 89.1% (86.9-91.0%). As expected, the highest effectiveness during this period was obtained in the group that received the third and fourth doses-96.5% (75.0-99.5%). The severity of COVID-19 in the vaccinated group was significantly lower than in the unvaccinated group.
医务人员是经常接触传染源的群体，因此感染传染病的风险更高。对这一群体进行特定疾病预防是当务之急。由于出现了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒的新关注变体，针对医务人员群体预防新冠病毒病（COVID-19）的流行病学有效性尚未得到充分深入研究。我们在莫斯科一家大型妇产科医疗中心开展了一项关于使用疫苗保护医务人员有效性的研究。卫星V疫苗和卫星-Light疫苗是预防COVID-19的主要疫苗。这些疫苗基于SARS-CoV-2病毒S蛋白的一种变体，以5型和26型腺病毒血清型作为递送载体。员工接种疫苗期间正值德尔塔变体传播时期。在德尔塔变体占主导的时期，总体流行病学有效性为81.7%（73.1-87.6%）。在从接种开始（2020年11月26日）至2022年2月8日期间，总体有效性为89.1%（86.9-91.0%）。正如预期的那样，在此期间，接种第三剂和第四剂的人群有效性最高，为96.5%（75.0-99.5%）。接种疫苗组中COVID-19的严重程度显著低于未接种疫苗组。
